| PROGINS polymorphism of progesterone receptor is increased in female offspring with maternal exposure to diethylstilbestrol. | |
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MedLine Citation:
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PMID: 11326686 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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DES (Diethylstilbestrol) was used for the treatment of corpus luteum insufficiences in early pregnancy. Prenatal exposure to DES leads to an increased frequency of vaginal cancer in female offspring. DES causes persistent alterations of steroid hormone binding in the vaginal tissue. The frequency of a polymorphism (PROGINS) of human progesterone receptor (hPR) gene which is associated with an increased risk of sporadic ovarian cancer was tested in DES-exposed offspring with vaginal dysplasia. Genomic DNA was isolated from the serum of 15 US Caucasian DES-offspring. PROGINS analysis was performed using sequencing, gel-electrophoresis and SSCP-PCR. The results demonstrated that the frequency of PROGINS is increased in DES-offspring (DES: 6.7% homozygous, 26.7% heterozygous, normal US Caucasians: 3.3% homozygous, 15% heterozygous). Mutation screening of PROGINS is an important advantage for the clinical management of screening and can give additional information to prevent or find vaginal cancer in early stages in DES-offspring. |
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Authors:
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D G Engehausen; K M Schrott |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anticancer research Volume: 20 ISSN: 0250-7005 ISO Abbreviation: Anticancer Res. Publication Date: 2000 Nov-Dec |
Date Detail:
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Created Date: 2001-04-30 Completed Date: 2001-05-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
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Languages: eng Pagination: 5145-9 Citation Subset: IM |
Affiliation:
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Department of Urology, University of Erlangen, Krankenhausstrasse 12, D-91054 Erlangen, Germany. Dirk.Engehausen@uro.imed.uni-erlangen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Carcinogens
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toxicity* Diethylstilbestrol / toxicity* Female Humans Maternal Exposure Polymerase Chain Reaction Polymorphism, Genetic / drug effects* Polymorphism, Single-Stranded Conformational Receptors, Progesterone / drug effects, genetics* |
| Chemical | |
Reg. No./Substance:
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0/Carcinogens; 0/Receptors, Progesterone; 56-53-1/Diethylstilbestrol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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