| PRL-releasing peptide interacts with leptin to reduce food intake and body weight. | |
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MedLine Citation:
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PMID: 11796488 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PRL-releasing peptide (PrRP) is a novel anorexigen that reduces food intake and body weight gain in rats. In common with other anorexigens, PrRP mRNA expression is reduced during states of negative energy balance, i.e. lactation and fasting in female rats. In this study, we examined the interaction between PrRP and the adiposity signal, leptin, which interacts with a number of peptidergic systems in the brain to regulate energy homeostasis. Intracerebroventricular coadministration of 4 nmol PrRP and 1 microg leptin in rats resulted in additive reductions in nocturnal food intake and body weight gain and an increase in core body temperature compared with each peptide alone. We show also, by quantitative in situ hybridization, that PrRP mRNA is reduced in fasted male rats and obese Zucker rats, indicating that PrRP mRNA expression, like that of other anorexigens, may be regulated by leptin. Finally we show, using immunohistochemistry, that greater than 90% of PrRP neurons in all regions where PrRP is expressed contain leptin receptors. Thus, we provide evidence for PrRP neurons forming part of the leptin-sensitive brain circuitry involved in the regulation of food intake and energy homeostasis. |
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Authors:
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Kate L J Ellacott; Catherine B Lawrence; Nancy J Rothwell; Simon M Luckman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Endocrinology Volume: 143 ISSN: 0013-7227 ISO Abbreviation: Endocrinology Publication Date: 2002 Feb |
Date Detail:
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Created Date: 2002-01-17 Completed Date: 2002-02-28 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: United States |
Other Details:
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Languages: eng Pagination: 368-74 Citation Subset: AIM; IM |
Affiliation:
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School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature / drug effects Body Weight / drug effects* Depression, Chemical Dorsomedial Hypothalamic Nucleus / metabolism Drug Interactions Eating / drug effects* Energy Metabolism / drug effects Fluorescent Antibody Technique, Indirect Hypothalamic Hormones / administration & dosage, pharmacology* Immunohistochemistry In Situ Hybridization Injections, Intraventricular Leptin / administration & dosage, pharmacology* Male Neuropeptides / administration & dosage, pharmacology* Obesity / genetics Prolactin / metabolism Prolactin-Releasing Hormone Rats Rats, Sprague-Dawley Rats, Zucker Solitary Nucleus / metabolism Tyrosine 3-Monooxygenase / genetics, metabolism Ventromedial Hypothalamic Nucleus / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Hypothalamic Hormones; 0/Leptin; 0/Neuropeptides; 0/Prlh protein, rat; 0/Prolactin-Releasing Hormone; 9002-62-4/Prolactin; EC 1.14.16.2/Tyrosine 3-Monooxygenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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