Document Detail

PRL-releasing peptide interacts with leptin to reduce food intake and body weight.
MedLine Citation:
PMID:  11796488     Owner:  NLM     Status:  MEDLINE    
PRL-releasing peptide (PrRP) is a novel anorexigen that reduces food intake and body weight gain in rats. In common with other anorexigens, PrRP mRNA expression is reduced during states of negative energy balance, i.e. lactation and fasting in female rats. In this study, we examined the interaction between PrRP and the adiposity signal, leptin, which interacts with a number of peptidergic systems in the brain to regulate energy homeostasis. Intracerebroventricular coadministration of 4 nmol PrRP and 1 microg leptin in rats resulted in additive reductions in nocturnal food intake and body weight gain and an increase in core body temperature compared with each peptide alone. We show also, by quantitative in situ hybridization, that PrRP mRNA is reduced in fasted male rats and obese Zucker rats, indicating that PrRP mRNA expression, like that of other anorexigens, may be regulated by leptin. Finally we show, using immunohistochemistry, that greater than 90% of PrRP neurons in all regions where PrRP is expressed contain leptin receptors. Thus, we provide evidence for PrRP neurons forming part of the leptin-sensitive brain circuitry involved in the regulation of food intake and energy homeostasis.
Kate L J Ellacott; Catherine B Lawrence; Nancy J Rothwell; Simon M Luckman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Endocrinology     Volume:  143     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-01-17     Completed Date:  2002-02-28     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  368-74     Citation Subset:  AIM; IM    
School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom.
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MeSH Terms
Body Temperature / drug effects
Body Weight / drug effects*
Depression, Chemical
Dorsomedial Hypothalamic Nucleus / metabolism
Drug Interactions
Eating / drug effects*
Energy Metabolism / drug effects
Fluorescent Antibody Technique, Indirect
Hypothalamic Hormones / administration & dosage,  pharmacology*
In Situ Hybridization
Injections, Intraventricular
Leptin / administration & dosage,  pharmacology*
Neuropeptides / administration & dosage,  pharmacology*
Obesity / genetics
Prolactin / metabolism
Prolactin-Releasing Hormone
Rats, Sprague-Dawley
Rats, Zucker
Solitary Nucleus / metabolism
Tyrosine 3-Monooxygenase / genetics,  metabolism
Ventromedial Hypothalamic Nucleus / metabolism
Reg. No./Substance:
0/Hypothalamic Hormones; 0/Leptin; 0/Neuropeptides; 0/Prlh protein, rat; 0/Prolactin-Releasing Hormone; 9002-62-4/Prolactin; EC 3-Monooxygenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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