Document Detail

PRES: the controlled noninvasive stimulation of the carotid baroreceptors in humans.
MedLine Citation:
PMID:  1635958     Owner:  NLM     Status:  MEDLINE    
To study physiological and psychological effects of baroreceptor activity, the cervical neck cuff technique has been frequently used to stimulate the carotid baroreceptors mechanically. Using this technique, no satisfying control conditions to date have been available. Because the carotid stretch receptors are sensitive not only to the pressure level, but also to the rate of change, it is possible to manipulate the receptor firing through changes in carotid pulse amplitude. The device described here relies on the application of short changes in cuff pressure tied to different phases within the cardiac cycle (phase related external suction (PRES)). A brief external suction during systole has potent stimulatory effects on baroreceptors whereas the application of the very same pressure pulse during diastole inhibits the firing burst associated with the pulse wave. To allow an ongoing period of stimulation, a sequence of alternating negative/positive pressure pulses is applied. In the stimulation condition, the R-wave of the electrocardiogram triggers a negative pulse which is followed by a positive one during diastole. In the control condition this relationship is reversed. Two experiments are reported confirming different baroreceptor effects of the two conditions. PRES allows for blind or double-blind experiments to investigate effects of baroreceptor activity on physiology and behavior.
H Rau; T Elbert; B Geiger; W Lutzenberger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychophysiology     Volume:  29     ISSN:  0048-5772     ISO Abbreviation:  Psychophysiology     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-08-24     Completed Date:  1992-08-24     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0142657     Medline TA:  Psychophysiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  165-72     Citation Subset:  IM    
Clinical and Physiological Psychology, Eberhard-Karls University, Tübingen, Germany.
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MeSH Terms
Blood Pressure / physiology
Carotid Arteries / physiology*
Heart Rate / physiology
Middle Aged
Neck / physiology
Physical Stimulation / instrumentation*
Pressoreceptors / physiology*

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