Document Detail

PR8 influenza virus infection impairs serum thymic activity levels and thymus-derived immune functions in mice.
MedLine Citation:
PMID:  2864045     Owner:  NLM     Status:  MEDLINE    
The levels of serum thymic activity (STA), the Thy-1.2 positivity of spleen "spontaneous" rosette-forming cells (SSRFCs) (measured in terms of Az sensitivity), as well as the blastogenic response to specific mitogens for T-lymphocytes, were studied in Balb/C mice after intranasal infection with A/PR/8/34 (HON1) influenza virus. As early as 12 hours, and more drastically, 24 hours the levels of STA were profoundly decreased after virus infection. Spleen Az sensitivity and blastogenic response of thymocytes and splenocytes to stimulation with Concanavalin A and Phytohemagglutinin, respectively, were depressed only later (day 2 or 3). These changes remain evident for about 1 week and later revert to normal values. All of the effects described are dose-dependent and appear to be virus related. Thence the PR8 virus infection initially induces a decrease of STA levels and secondly a impairment of thymus-derived immune functions.
V Del Gobbo; N Caliò-Villani; E Garaci; R Caliò
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bollettino dell'Istituto sieroterapico milanese     Volume:  64     ISSN:  0021-2547     ISO Abbreviation:  Boll Ist Sieroter Milan     Publication Date:  1985  
Date Detail:
Created Date:  1985-11-19     Completed Date:  1985-11-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  17720040R     Medline TA:  Boll Ist Sieroter Milan     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  207-15     Citation Subset:  IM    
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MeSH Terms
Antigens, Surface / analysis
Antigens, Thy-1
Azathioprine / pharmacology
Cell Division
Concanavalin A / pharmacology
Dose-Response Relationship, Drug
Influenza A virus
Lymphocyte Activation / drug effects
Mice, Inbred BALB C
Orthomyxoviridae Infections / immunology*
Phytohemagglutinins / pharmacology
Rosette Formation
Spleen / drug effects
T-Lymphocytes / immunology*
Thymic Factor, Circulating / analysis*
Thymus Hormones / analysis*
Time Factors
Reg. No./Substance:
0/Antigens, Surface; 0/Antigens, Thy-1; 0/Phytohemagglutinins; 0/Thymus Hormones; 11028-71-0/Concanavalin A; 446-86-6/Azathioprine; 78922-62-0/Thymic Factor, Circulating

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