Document Detail

PR interval behavior during exercise: implications for physiological pacemakers.
MedLine Citation:
PMID:  1704529     Owner:  NLM     Status:  MEDLINE    
The relationship between heart rate response and the dynamic changes in the PR interval was assessed in 631 patients undergoing routine cardiac exercise tests for a variety of clinical indications. Patients were stratified into four subsets: nonmedicated normals (n = 437), patients on beta-antagonist agents (n = 118), those on antiarrhythmic agents alone (n = 61) and those with a clinical diagnosis of advanced (New York Heart Association [NYHA] Class III or IV) congestive heart failure. All patients were in stable sinus rhythm throughout the test. PR intervals were measured at rest, at mid-exercise and at peak exercise. Mean PR intervals shortened to a statistically significant degree in most subgroups. This effect was predominantly observed in the earlier stages of exercise. In patients with advanced heart failure, there was no statistically significant shortening of exercise PR intervals later in exercise, demonstrating a parallel with their relatively blunted heart rate response. These changes in exercise PR intervals suggest that implanted pacemaker algorithms may be constructed to maximize hemodynamic benefit in patients requiring physiological pacemakers.
R M Luceri; S L Brownstein; L Vardeman; S Goldstein
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  13     ISSN:  0147-8389     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-03-19     Completed Date:  1991-03-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1719-23     Citation Subset:  IM    
Interventional Cardiac Arrhythmia Center, Holy Cross Hospital, Fort Lauderdale, Florida.
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MeSH Terms
Adrenergic beta-Antagonists / therapeutic use*
Aged, 80 and over
Anti-Arrhythmia Agents / therapeutic use*
Electrocardiography* / drug effects
Exercise Test
Heart Failure / physiopathology*
Heart Rate / drug effects,  physiology
Middle Aged
Pacemaker, Artificial*
Physical Exertion / physiology*
Retrospective Studies
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Anti-Arrhythmia Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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