Document Detail

PR and OTc interval prolongation on the electrocardiogram after binge drinking in healthy individuals.
MedLine Citation:
PMID:  15766009     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Acute, excessive alcohol intake has been associated with an increased cardiovascular mortality in otherwise healthy individuals. It predisposes to accelerated atherosclerosis resulting in acute coronary events but also arrhythmias have been described, such as atrial fibrillation and life-threatening re-entrant ventricular arrhythmias. QTc prolongation is associated with an increased risk of ventricular tachyarrhythmias and an independent risk factor for sudden cardiac death. The aim of the study is to investigate the effect of binge drinking on the conduction intervals in healthy individuals. METHODS: Ten of the volunteers drank red wine while the other ten volunteers drank a sweet designer drink. A follow-up of blood pressure, heart rate, ECG and laboratory findings was performed at an ethanol level of 0, 0.4 and 0.8%, respectively. RESULTS: Fifteen volunteers showed a prolongation of the PR interval, 13 of the QRS complex, 9 of the QT interval and 13 of the QTc interval. PR interval increased from 149 +/- 16 ms to 163 +/- 11 ms (p < 0.05). The heart rate-adjusted QT interval increased from 400 +/- 24 ms to 426 +/- 52 ms (p < 0.05). Heart rate and systolic blood pressure did not significantly change due to the ingestion. CONCLUSION: Acute ingestion of alcohol in a healthy population can induce prolongation of PR and QTc interval.
A Lorsheyd; D W de Lange; M L Hijmering; M J M Cramer; A van de Wiel
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Netherlands journal of medicine     Volume:  63     ISSN:  0300-2977     ISO Abbreviation:  Neth J Med     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-03-15     Completed Date:  2005-04-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0356133     Medline TA:  Neth J Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  59-63     Citation Subset:  IM    
Department of Internal Medicine, Meander Medical Centre, Amersfoort, The Netherlands.
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MeSH Terms
Alcoholic Intoxication / complications*
Ethanol / blood
Heart Conduction System / physiopathology*
Long QT Syndrome / chemically induced*,  diagnosis
Middle Aged
Prospective Studies
Risk Assessment
Sampling Studies
Sensitivity and Specificity
Reg. No./Substance:
Erratum In:
Neth J Med. 2005 Apr;63(4):136

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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