| PR and OTc interval prolongation on the electrocardiogram after binge drinking in healthy individuals. | |
MedLine Citation:
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PMID: 15766009 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Acute, excessive alcohol intake has been associated with an increased cardiovascular mortality in otherwise healthy individuals. It predisposes to accelerated atherosclerosis resulting in acute coronary events but also arrhythmias have been described, such as atrial fibrillation and life-threatening re-entrant ventricular arrhythmias. QTc prolongation is associated with an increased risk of ventricular tachyarrhythmias and an independent risk factor for sudden cardiac death. The aim of the study is to investigate the effect of binge drinking on the conduction intervals in healthy individuals. METHODS: Ten of the volunteers drank red wine while the other ten volunteers drank a sweet designer drink. A follow-up of blood pressure, heart rate, ECG and laboratory findings was performed at an ethanol level of 0, 0.4 and 0.8%, respectively. RESULTS: Fifteen volunteers showed a prolongation of the PR interval, 13 of the QRS complex, 9 of the QT interval and 13 of the QTc interval. PR interval increased from 149 +/- 16 ms to 163 +/- 11 ms (p < 0.05). The heart rate-adjusted QT interval increased from 400 +/- 24 ms to 426 +/- 52 ms (p < 0.05). Heart rate and systolic blood pressure did not significantly change due to the ingestion. CONCLUSION: Acute ingestion of alcohol in a healthy population can induce prolongation of PR and QTc interval. |
Authors:
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A Lorsheyd; D W de Lange; M L Hijmering; M J M Cramer; A van de Wiel |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Netherlands journal of medicine Volume: 63 ISSN: 0300-2977 ISO Abbreviation: Neth J Med Publication Date: 2005 Feb |
Date Detail:
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Created Date: 2005-03-15 Completed Date: 2005-04-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0356133 Medline TA: Neth J Med Country: Netherlands |
Other Details:
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Languages: eng Pagination: 59-63 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Meander Medical Centre, Amersfoort, The Netherlands. alorshey@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alcoholic Intoxication / complications* Electrocardiography* Ethanol / blood Female Heart Conduction System / physiopathology* Humans Long QT Syndrome / chemically induced*, diagnosis Male Middle Aged Probability Prospective Studies Risk Assessment Sampling Studies Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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64-17-5/Ethanol |
| Comments/Corrections | |
Erratum In:
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Neth J Med. 2005 Apr;63(4):136 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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