Document Detail


PQQ and quinoprotein research--the first decade.
MedLine Citation:
PMID:  2560373     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
On the occasion of the first international symposium on pyrroloquinoline quinone (PQQ) and quinoproteins (Delft, September 1988), a review of this novel field in enzymology is presented. Quinoproteins (PQQ-containing enzymes) are widespread, from bacteria to mammalian organisms (including man), and occur in several classes of enzymes. Indications already exist that PQQ is a versatile cofactor, involved not only in oxidation but also in hydroxylation, transamination, decarboxylation and hydration reactions. The current list of quinoproteins shows that it was overlooked in several well-studied enzymes where the presence of a common cofactor had already been established. Up until now, all eukaryotic quinoproteins have covalently bound PQQ (or perhaps pro-PQQ), while free PQQ occurs exclusively in a number of (bacterial) dehydrogenases and in the culture fluid of certain Gram-negative bacteria. Biosynthesis of free PQQ in methylotrophic bacteria starts with tyrosine and glutamic acid as precursors while intermediates in the route have not been detected and the presence of free PQQ is not required for synthesis of the covalently bound form of the cofactor in glutamic acid decarboxylase from Escherichia coli. Therefore, the assembly of covalently bound cofactor might occur in situ, i.e. in the quinoproteins themselves. If the latter also applies to mammalian quinoproteins, this implies that PQQ is not a vitamin. On the other hand, positive effects have been reported upon administration of PQQ to test animals. Methods suited to detach and to detect PQQ with a derivatized o-quinone moiety may answer questions on the uptake and processing of the compound.
Authors:
J A Duine
Related Documents :
9287363 - Recent nutritional approaches to the prevention and therapy of cardiovascular disease.
16214333 - Synergistic effect of folic acid and vitamin b12 in ameliorating arsenic-induced oxidat...
14425983 - Studies on independent synthesis of cytoplasmic ribonucleic acids in acetabularia medit...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  BioFactors (Oxford, England)     Volume:  2     ISSN:  0951-6433     ISO Abbreviation:  Biofactors     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-04-04     Completed Date:  1990-04-04     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8807441     Medline TA:  Biofactors     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  87-94     Citation Subset:  IM    
Affiliation:
Department of Microbiology and Enzymology, Delft University of Technology, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Bacteria / enzymology*
Enzymes / metabolism*
PQQ Cofactor
Quinolones / pharmacology*
Chemical
Reg. No./Substance:
0/Enzymes; 0/Quinolones; 72909-34-3/PQQ Cofactor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Reaction of pyridoxamine-5-P with pyrroloquinoline quinone (coenzyme PQQ).
Next Document:  Derivatives of glutamic acid and trehalose which can be transformed into long-living free radicals b...