| PQ interval in patients with Fabry disease. | |
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MedLine Citation:
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PMID: 20185028 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fabry disease (FD) is an X-chromosomal inherited lysosomal storage disease resulting in intracellular storage of globotriaosylceramide. Cardiac involvement is most frequently manifested as left ventricular hypertrophy. However, patients with FD may also have from various conduction abnormalities particularly affecting atrioventricular (AV) conduction. The present study was designed to analyze primarily AV conduction abnormalities on baseline electrocardiograms of patients with FD and to investigate the correlation with echocardiographic findings. Electrocardiograms at rest of 207 patients with FD were compared to echocardiograms. PQ-interval shortening and first-degree AV block could be found in only 29 cases (14%) and 3 cases (1.4%), respectively. No echocardiographic differences could be found in patients with and without PQ-interval shortening, including left ventricular hypertrophy, atrial size, and diastolic parameters. Furthermore, no correlation of the PQ interval with any echocardiographic parameters was detected. There was no difference between men and women in baseline clinical and electrocardiographic parameters. In conclusion, shortening of the PQ interval was not a common electrocardiographic finding in patients newly diagnosed with FD. Furthermore, no correlation with typical echocardiographic findings or disease stage in FD at baseline could be found. |
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Authors:
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Mehdi Namdar; Christoph Kampmann; Jan Steffel; Daniel Walder; Johannes Holzmeister; Thomas Felix L?scher; Rolf Jenni; Firat Duru |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of cardiology Volume: 105 ISSN: 1879-1913 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-26 Completed Date: 2010-04-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 753-6 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Clinic for Cardiology, University Hospital of Zurich, Zurich, Switzerland. mehdi.namdar@usz.ch |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arrhythmias, Cardiac / epidemiology*, physiopathology, ultrasonography Atrioventricular Block / epidemiology*, physiopathology, ultrasonography Cohort Studies Echocardiography, Doppler Electrocardiography Fabry Disease / complications, physiopathology*, ultrasonography* Female Humans Hypertrophy, Left Ventricular / complications, physiopathology, ultrasonography Male Middle Aged Prevalence Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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