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PPARs in the Renal Regulation of Systemic Blood Pressure.
MedLine Citation:
PMID:  20613959     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Recent research has revealed roles for the peroxisome proliferator activated receptor (PPAR) family of transcription factors in blood pressure regulation, expanding the possible therapeutic use of PPAR ligands. PPARalpha and PPARgamma modulate the renin-angiotensin-aldosterone system (RAAS), a major regulator of systemic blood pressure and interstitial fluid volume by transcriptional control of renin, angiotensinogen, angiotensin converting enzyme (ACE) and angiotensin II receptor 1 (AT-R1). Blockade of RAAS is an important therapeutic target in hypertension management and attenuates microvascular damage, glomerular inflammation and left ventricular hypertrophy in hypertensive patients and also show antidiabetic effects. The mechanisms underlying the benefits of RAAS inhibition appear to involve PPARgamma-regulated pathways. This review summarizes current knowledge on the role of PPARs in the transcriptional control of the RAAS and the possible use of PPAR ligands in the treatment of RAAS dependent hypertension.
Authors:
Tamás Roszer; Mercedes Ricote
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Publication Detail:
Type:  Journal Article     Date:  2010-06-08
Journal Detail:
Title:  PPAR research     Volume:  2010     ISSN:  1687-4765     ISO Abbreviation:  PPAR Res     Publication Date:  2010  
Date Detail:
Created Date:  2010-07-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101269101     Medline TA:  PPAR Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  698730     Citation Subset:  -    
Affiliation:
Department of Regenerative Cardiology, Spanish National Cardiovascular Research Center (CNIC), 28029 Madrid, Spain.
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