| PPARgamma stimulation promotes neurite outgrowth in SH-SY5Y human neuroblastoma cells. | |
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MedLine Citation:
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PMID: 19429070 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several evidences indicate that PPARgamma stimulation promotes neuronal differentiation. However, to date, no data describe the effects of PPARgamma agonists on neurite outgrowth. Here we have evaluated the effects of pioglitazone, a synthetic PPARgamma agonist, on differentiation and neurite outgrowth in SH-SY5Y human neuroblastoma cells. Our results show that pioglitazone promotes cell differentiation and the outgrowth of cell processes in a concentration-dependent manner with the maximal effect at 100 nM-1 microM. It significantly increases both the mean process length and the percentage of neurite-bearing cells. In addition, these effects are accompanied by significant activation of p42 and p44 mitogen-activated protein kinases. In conclusion, albeit preliminary, these findings suggest the possibility that PPARgamma stimulation may contribute to the development and maintenance of a proper neuronal connectivity within neuronal networks. |
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Authors:
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Gianluca Miglio; Lorenza Rattazzi; Arianna C Rosa; Roberto Fantozzi |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-03-11 |
Journal Detail:
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Title: Neuroscience letters Volume: 454 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-05-11 Completed Date: 2009-08-17 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 134-8 Citation Subset: IM |
Affiliation:
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Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, Via Pietro Giuria 9, 10125 Turin, Italy. gianluca.miglio@unito.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Blotting, Western Cell Line, Tumor Dose-Response Relationship, Drug Enzyme Activation Humans Mitogen-Activated Protein Kinase 1 / metabolism Mitogen-Activated Protein Kinase 3 / metabolism Neurites / drug effects, physiology* Neurogenesis / drug effects* PPAR gamma / agonists, metabolism* Thiazolidinediones / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/PPAR gamma; 0/Thiazolidinediones; 111025-46-8/pioglitazone; EC 2.7.11.24/Mitogen-Activated Protein Kinase 1; EC 2.7.11.24/Mitogen-Activated Protein Kinase 3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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