| PPARgamma controls dectin-1 expression required for host antifungal defense against Candida albicans. | |
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MedLine Citation:
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PMID: 20062524 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We recently showed that IL-13 or peroxisome proliferator activated receptor gamma (PPARgamma) ligands attenuate Candida albicans colonization of the gastrointestinal tract. Here, using a macrophage-specific Dectin-1 deficient mice model, we demonstrate that Dectin-1 is essential to control fungal gastrointestinal infection by PPARgamma ligands. We also show that the phagocytosis of yeast and the release of reactive oxygen intermediates in response to Candida albicans challenge are impaired in macrophages from Dectin-1 deficient mice treated with PPARgamma ligands or IL-13. Although the Mannose Receptor is not sufficient to trigger antifungal functions during the alternative activation of macrophages, our data establish the involvement of the Mannose Receptor in the initial recognition of non-opsonized Candida albicans by macrophages. We also demonstrate for the first time that the modulation of Dectin-1 expression by IL-13 involves the PPARgamma signaling pathway. These findings are consistent with a crucial role for PPARgamma in the alternative activation of macrophages by Th2 cytokines. Altogether these data suggest that PPARgamma ligands may be of therapeutic value in esophageal and gastrointestinal candidiasis in patients severely immunocompromised or with metabolic diseases in whom the prevalence of candidiasis is considerable. |
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Authors:
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Amandine Galès; Annabelle Conduché; José Bernad; Lise Lefevre; David Olagnier; Maryse Béraud; Guillaume Martin-Blondel; Marie-Denise Linas; Johan Auwerx; Agnès Coste; Bernard Pipy |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-08 |
Journal Detail:
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Title: PLoS pathogens Volume: 6 ISSN: 1553-7374 ISO Abbreviation: PLoS Pathog. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-11 Completed Date: 2010-03-09 Revised Date: 2010-09-28 |
Medline Journal Info:
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Nlm Unique ID: 101238921 Medline TA: PLoS Pathog Country: United States |
Other Details:
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Languages: eng Pagination: e1000714 Citation Subset: IM |
Affiliation:
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UMR-MD3 EA2405 Université de Toulouse III; UPS; Polarisation des Macrophages et Récepteurs Nucléaires dans les Pathologies Inflammatoires et Infectieuses, PMRNP2I, Toulouse, France. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Candida albicans / immunology Candidiasis / immunology*, metabolism Cell Separation Flow Cytometry Interleukin-13 / immunology, metabolism Lectins, C-Type / immunology, metabolism Macrophage Activation / immunology Macrophages / immunology, metabolism* Mannose-Binding Lectins / immunology, metabolism Membrane Proteins / immunology, metabolism* Mice Mice, Knockout Nerve Tissue Proteins / immunology, metabolism* PPAR gamma / immunology, metabolism* Phagocytosis / immunology Reactive Oxygen Species / immunology, metabolism Receptors, Cell Surface / immunology, metabolism Reverse Transcriptase Polymerase Chain Reaction Signal Transduction / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-13; 0/Lectins, C-Type; 0/Mannose-Binding Lectins; 0/Membrane Proteins; 0/Nerve Tissue Proteins; 0/PPAR gamma; 0/Reactive Oxygen Species; 0/Receptors, Cell Surface; 0/dectin 1; 0/mannose receptor |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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