Document Detail


PPARgamma as a therapeutic target in central nervous system diseases.
MedLine Citation:
PMID:  16766086     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Diseases of the central nervous system present a challenge for the development of new therapeutic agents. Nuclear receptors are ligand-activated transcription factors that have proven to be valuable targets for development of new drugs owing to their ability to directly regulate gene expression. The nuclear receptor, peroxisome proliferator-activated receptor gamma (PPARgamma), has been investigated for its action in ameliorating the development and progression of a number of CNS diseases. PPARgamma agonists exhibit potent anti-inflammatory effects and appear to have direct neuroprotective actions. PPARgamma agonists have been shown to be efficacious in animal models of Alzheimer's disease, stroke, multiple sclerosis, Parkinson's disease and amyotrophic lateral sclerosis. The availability of FDA-approved agonists of this receptor will facilitate the rapid translation of these findings into clinical trials for a number of CNS diseases.
Authors:
Sophia Sundararajan; Qingguang Jiang; Michael Heneka; Gary Landreth
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Publication Detail:
Type:  Journal Article; Review     Date:  2006-06-12
Journal Detail:
Title:  Neurochemistry international     Volume:  49     ISSN:  0197-0186     ISO Abbreviation:  Neurochem. Int.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-19     Completed Date:  2006-09-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8006959     Medline TA:  Neurochem Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  136-44     Citation Subset:  IM    
Affiliation:
Department of Neurology, Case Western Reserve University, Cleveland, OH 44106-4928, United States.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Inflammatory Agents / pharmacology*,  therapeutic use
Brain / drug effects*,  immunology,  physiopathology
Brain Diseases / drug therapy*,  immunology,  physiopathology
Disease Models, Animal
Encephalitis / drug therapy*,  genetics,  immunology
Gene Expression Regulation / drug effects,  genetics,  immunology
Humans
Inflammation Mediators / antagonists & inhibitors,  immunology,  metabolism
Neuroprotective Agents / pharmacology*,  therapeutic use
PPAR gamma / agonists*,  immunology,  metabolism
Transcriptional Activation / drug effects,  genetics,  immunology
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Inflammation Mediators; 0/Neuroprotective Agents; 0/PPAR gamma

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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