| PPARgamma as a therapeutic target in central nervous system diseases. | |
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MedLine Citation:
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PMID: 16766086 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Diseases of the central nervous system present a challenge for the development of new therapeutic agents. Nuclear receptors are ligand-activated transcription factors that have proven to be valuable targets for development of new drugs owing to their ability to directly regulate gene expression. The nuclear receptor, peroxisome proliferator-activated receptor gamma (PPARgamma), has been investigated for its action in ameliorating the development and progression of a number of CNS diseases. PPARgamma agonists exhibit potent anti-inflammatory effects and appear to have direct neuroprotective actions. PPARgamma agonists have been shown to be efficacious in animal models of Alzheimer's disease, stroke, multiple sclerosis, Parkinson's disease and amyotrophic lateral sclerosis. The availability of FDA-approved agonists of this receptor will facilitate the rapid translation of these findings into clinical trials for a number of CNS diseases. |
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Authors:
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Sophia Sundararajan; Qingguang Jiang; Michael Heneka; Gary Landreth |
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Publication Detail:
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Type: Journal Article; Review Date: 2006-06-12 |
Journal Detail:
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Title: Neurochemistry international Volume: 49 ISSN: 0197-0186 ISO Abbreviation: Neurochem. Int. Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-06-19 Completed Date: 2006-09-14 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8006959 Medline TA: Neurochem Int Country: England |
Other Details:
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Languages: eng Pagination: 136-44 Citation Subset: IM |
Affiliation:
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Department of Neurology, Case Western Reserve University, Cleveland, OH 44106-4928, United States. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Inflammatory Agents / pharmacology*, therapeutic use Brain / drug effects*, immunology, physiopathology Brain Diseases / drug therapy*, immunology, physiopathology Disease Models, Animal Encephalitis / drug therapy*, genetics, immunology Gene Expression Regulation / drug effects, genetics, immunology Humans Inflammation Mediators / antagonists & inhibitors, immunology, metabolism Neuroprotective Agents / pharmacology*, therapeutic use PPAR gamma / agonists*, immunology, metabolism Transcriptional Activation / drug effects, genetics, immunology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Inflammation Mediators; 0/Neuroprotective Agents; 0/PPAR gamma |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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