| PPAR{gamma} activation prevents hypertensive remodeling of cerebral arteries and improves vascular function in female rats. | |
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MedLine Citation:
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PMID: 20395611 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: Previous studies have shown that peroxisome proliferator-activated receptor gamma (PPARgamma), a ligand-activated transcription factor expressed in vascular cells, is protective of the vasculature. We hypothesized that activation of PPARgamma could prevent hypertensive remodeling of cerebral arteries and improve vascular function. METHODS: Ten female Sprague-Dawley rats were treated with the nitric oxide synthase inhibitor N(G)-nitro-l-arginine methyl ester (l-NAME) for 5 weeks, 8 were treated with l-NAME plus the PPARgamma activator rosiglitazone, and 8 received no treatment and served as controls. Blood pressure, myogenic activity, passive diameters and wall thickness of cerebral arteries, and brain capillary density were compared between the groups. RESULTS: Treatment with l-NAME caused an increase in arterial blood pressure that was sustained with rosiglitazone treatment. l-NAME also caused inward hypertrophic remodeling and enhanced myogenic reactivity of cerebral arteries that was reversed by rosiglitazone. In addition, l-NAME hypertension caused rarefaction of brain capillaries by approximately 12%, whereas treatment with rosiglitazone increased capillary density by approximately 20%. CONCLUSIONS: PPARgamma activation may be an effective and clinically relevant way to prevent hypertensive remodeling of cerebral arteries and capillary rarefaction as well as improving vascular function without affecting blood pressure. |
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Authors:
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Marilyn J Cipolla; Nicole Bishop; R Saman Vinke; Julie A Godfrey |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-04-15 |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 41 ISSN: 1524-4628 ISO Abbreviation: Stroke Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-25 Completed Date: 2010-06-11 Revised Date: 2011-11-24 |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: United States |
Other Details:
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Languages: eng Pagination: 1266-70 Citation Subset: IM |
Affiliation:
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Department of Neurology, University of Vermont, 89 Beaumont Avenue, Given C454, Burlington, VT 05405, USA. Marilyn.Cipolla@uvm.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Brain / blood supply, physiopathology Capillaries / physiopathology Cerebral Arteries / metabolism, physiopathology* Enzyme Inhibitors / pharmacology Female Hypertension / chemically induced, metabolism, physiopathology* Hypoglycemic Agents / pharmacology* NG-Nitroarginine Methyl Ester / pharmacology PPAR gamma / agonists*, metabolism Rats Rats, Sprague-Dawley Thiazolidinediones / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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NS043316/NS/NINDS NIH HHS; NS045940/NS/NINDS NIH HHS; R01 NS043316-05/NS/NINDS NIH HHS; R01 NS045940-06/NS/NINDS NIH HHS; R01 NS045940-07/NS/NINDS NIH HHS; R01 NS045940-08/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 0/Hypoglycemic Agents; 0/PPAR gamma; 0/Thiazolidinediones; 122320-73-4/rosiglitazone; 50903-99-6/NG-Nitroarginine Methyl Ester |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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