| PPARalpha-dependent induction of the energy homeostasis-regulating nuclear receptor NR1i3 (CAR) in rat hepatocytes: potential role in starvation adaptation. | |
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MedLine Citation:
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PMID: 18023279 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A tight hormonal control of energy homeostasis is of pivotal relevance for animals. Recent evidence suggests an involvement of the nuclear receptor NR1i3 (CAR). Fasting induces CAR by largely unknown mechanisms and CAR-deficient mice are defective in fasting adaptation. In rat hepatocytes CAR was induced by WY14643, a PPARalpha-agonist. A DR1 motif in the CAR promoter was necessary and sufficient for this control. The PPARalpha-dependent increase in CAR potentiated the phenobarbital-induced transcription of the prototypical CAR-dependent gene CYP2B1. Since free fatty acids are natural ligands for PPARalpha, a fasting-induced increase in free fatty acids might induce CAR. In accordance with this hypothesis, CAR induction by fasting was abrogated in PPARalpha-deficient mice. |
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Authors:
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Nadine Wieneke; Karen I Hirsch-Ernst; Manuela Kuna; Sander Kersten; Gerhard P Püschel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-11-20 |
Journal Detail:
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Title: FEBS letters Volume: 581 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-12-06 Completed Date: 2008-03-26 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 5617-26 Citation Subset: IM |
Affiliation:
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Universität Potsdam, Institut für Ernährungswissenschaft, Biochemie der Ernährung, Arthur-Scheunert-Allee 114-116, D-14558, Nuthetal, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological* Animals Cytochrome P-450 CYP2B1 / metabolism Energy Metabolism Gene Expression Regulation* Hepatocytes / metabolism Male Mice Mice, Transgenic PPAR alpha / agonists, metabolism* Promoter Regions, Genetic Pyrimidines / pharmacology Rats Rats, Wistar Receptors, Cytoplasmic and Nuclear / genetics*, metabolism Starvation / genetics*, metabolism Transcription Factors / genetics*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/PPAR alpha; 0/Pyrimidines; 0/Receptors, Cytoplasmic and Nuclear; 0/Transcription Factors; 0/constitutive androstane receptor; 50892-23-4/pirinixic acid; EC 1.14.14.1/Cytochrome P-450 CYP2B1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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