| PPAR-gamma ligands and amino acid deprivation promote apoptosis of melanoma, prostate, and breast cancer cells. | |
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MedLine Citation:
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PMID: 15979236 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The PPAR-gamma ligands, 15-deoxy-Delta(12,14)-prostaglandin J(2) and ciglitazone, and the PPAR-alpha ligand, WY-14643, were examined for their effects on proliferation and apoptosis of A375 melanoma, DU145 and PC3 prostate cancer, and MB-MDA-231 breast cancer. While 15-deoxy-Delta(12,14)-prostaglandin J(2) inhibited proliferation of A375 melanoma, ciglitazone was inactive against this and the other cell lines. Restriction of specific amino acids known to inhibit proliferation and induce apoptosis sensitized all cell lines to ciglitazone, and the combined effects were greater than the individual effects of either treatment. WY-14643 alone or in combination with amino acid deprivation was inactive. Normal fibroblasts were resistant to the treatments. |
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Authors:
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Nomelí P Núñez; Huaitian Liu; Gary G Meadows |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural Date: 2005-06-23 |
Journal Detail:
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Title: Cancer letters Volume: 236 ISSN: 0304-3835 ISO Abbreviation: Cancer Lett. Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-04-25 Completed Date: 2006-06-28 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 133-41 Citation Subset: IM |
Affiliation:
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Cancer Prevention & Research Center, The Pharmacology and Toxicology Graduate Program, Department of Pharmaceutical Sciences, and the College of Pharmacy, Washington State University, Pullman, WA 99164-6713, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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deficiency* Antineoplastic Agents / pharmacology* Apoptosis* Breast Neoplasms Cell Line, Tumor Cell Proliferation / drug effects Cell Survival / drug effects Dose-Response Relationship, Drug Female Humans Hypoglycemic Agents / pharmacology Immunologic Factors / pharmacology Ligands Male Melanoma Methionine / deficiency PPAR gamma / metabolism* Phenylalanine / deficiency Prostaglandin D2 / analogs & derivatives*, pharmacology Prostatic Neoplasms Thiazolidinediones / pharmacology* Tyrosine / deficiency |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA10135/CA/NCI NIH HHS; R01 CA77604/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/15-deoxy-delta(12,14)-prostaglandin J2; 0/Amino Acids; 0/Antineoplastic Agents; 0/Hypoglycemic Agents; 0/Immunologic Factors; 0/Ligands; 0/PPAR gamma; 0/Thiazolidinediones; 41598-07-6/Prostaglandin D2; 55520-40-6/Tyrosine; 63-68-3/Methionine; 63-91-2/Phenylalanine; 74772-77-3/ciglitazone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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