Document Detail


PPAR-gamma ligands and amino acid deprivation promote apoptosis of melanoma, prostate, and breast cancer cells.
MedLine Citation:
PMID:  15979236     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The PPAR-gamma ligands, 15-deoxy-Delta(12,14)-prostaglandin J(2) and ciglitazone, and the PPAR-alpha ligand, WY-14643, were examined for their effects on proliferation and apoptosis of A375 melanoma, DU145 and PC3 prostate cancer, and MB-MDA-231 breast cancer. While 15-deoxy-Delta(12,14)-prostaglandin J(2) inhibited proliferation of A375 melanoma, ciglitazone was inactive against this and the other cell lines. Restriction of specific amino acids known to inhibit proliferation and induce apoptosis sensitized all cell lines to ciglitazone, and the combined effects were greater than the individual effects of either treatment. WY-14643 alone or in combination with amino acid deprivation was inactive. Normal fibroblasts were resistant to the treatments.
Authors:
Nomelí P Núñez; Huaitian Liu; Gary G Meadows
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2005-06-23
Journal Detail:
Title:  Cancer letters     Volume:  236     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-04-25     Completed Date:  2006-06-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  133-41     Citation Subset:  IM    
Affiliation:
Cancer Prevention & Research Center, The Pharmacology and Toxicology Graduate Program, Department of Pharmaceutical Sciences, and the College of Pharmacy, Washington State University, Pullman, WA 99164-6713, USA.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / deficiency*
Antineoplastic Agents / pharmacology*
Apoptosis*
Breast Neoplasms
Cell Line, Tumor
Cell Proliferation / drug effects
Cell Survival / drug effects
Dose-Response Relationship, Drug
Female
Humans
Hypoglycemic Agents / pharmacology
Immunologic Factors / pharmacology
Ligands
Male
Melanoma
Methionine / deficiency
PPAR gamma / metabolism*
Phenylalanine / deficiency
Prostaglandin D2 / analogs & derivatives*,  pharmacology
Prostatic Neoplasms
Thiazolidinediones / pharmacology*
Tyrosine / deficiency
Grant Support
ID/Acronym/Agency:
R01 CA10135/CA/NCI NIH HHS; R01 CA77604/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/15-deoxy-delta(12,14)-prostaglandin J2; 0/Amino Acids; 0/Antineoplastic Agents; 0/Hypoglycemic Agents; 0/Immunologic Factors; 0/Ligands; 0/PPAR gamma; 0/Thiazolidinediones; 41598-07-6/Prostaglandin D2; 55520-40-6/Tyrosine; 63-68-3/Methionine; 63-91-2/Phenylalanine; 74772-77-3/ciglitazone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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