Document Detail

PPAR-gamma Pro12Ala genotype and risk of cognitive decline in elders.
MedLine Citation:
PMID:  17052804     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) has been associated with decreased risk of diabetes and obesity, both disorders linked to cognitive impairment. We tested whether this polymorphism is associated with cognition.
METHODS: Two thousand nine hundred sixty-one participants (mean age, 74.1; 41% Black; 52% women) were administered the Modified Mini-Mental State Examination (3MS) and Digit Symbol Substitution Test (DSST) at baseline and 4 year follow-up. Test scores were adjusted for age, sex, education, cerebrovascular disease, depression and APOE genotype and additionally for race. We determined the association between Ala allele and development of cognitive decline (3MS decline of > or = 5 points).
RESULTS: At baseline, unadjusted scores on both cognitive tests were higher for Ala carriers compared to non-carriers (3MS, 94.2 versus 92.5, p<0.001; DSST, 40.2 versus 34.5, p<0.001). Similarly, follow-up scores were higher for Ala carriers. Multivariable adjustment led to similar results; additional adjustment for race attenuated the baseline 3MS results. After 4 years, 17.5% of Ala carriers developed cognitive decline compared to 25% among non-carriers (unadjusted OR=0.61; 95%CI, 0.46-0.82; adjusted OR=0.75; 95%CI, 0.55-1.02). Further adjustment for metabolic variables including fasting blood glucose and lipid level did not change the results.
CONCLUSIONS: The PPAR-gamma Ala12 allele carriers may have less risk of developing cognitive decline.
K Yaffe; A M Kanaya; K Lindquist; W C Hsueh; S R Cummings; B Beamer; A Newman; C Rosano; R Li; T Harris;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural     Date:  2006-10-18
Journal Detail:
Title:  Neurobiology of aging     Volume:  29     ISSN:  1558-1497     ISO Abbreviation:  Neurobiol. Aging     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-11-21     Completed Date:  2008-01-31     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  8100437     Medline TA:  Neurobiol Aging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  78-83     Citation Subset:  IM    
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MeSH Terms
African Continental Ancestry Group
Aging / physiology*
Alanine / genetics*
Cognition Disorders / genetics*
European Continental Ancestry Group
Longitudinal Studies
Mental Status Schedule
Neuropsychological Tests
PPAR gamma / genetics*
Proline / genetics*
Retrospective Studies
Grant Support
AG021918-03/AG/NIA NIH HHS; DK070713/DK/NIDDK NIH HHS; N01-AG-6-2101/AG/NIA NIH HHS; N01-AG-6-2103/AG/NIA NIH HHS; N01-AG-6-2106/AG/NIA NIH HHS; R01 AG021918/AG/NIA NIH HHS; R01 AG021918-03/AG/NIA NIH HHS; R21 DK070713/DK/NIDDK NIH HHS; R21 DK070713-01/DK/NIDDK NIH HHS
Reg. No./Substance:
0/PPAR gamma; 9DLQ4CIU6V/Proline; OF5P57N2ZX/Alanine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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