| PPAR-gamma agonists and their role in type 2 diabetes mellitus management. | |
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MedLine Citation:
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PMID: 20216208 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Type 2 diabetes mellitus and obesity are the most frequent endocrine-metabolic diseases in the world and their pathogenic basis are characterized by insulin resistance and insulin secretion defects that can be demonstrated through several alterations in carbohydrates, lipids, and protein metabolism. The peroxisome proliferator-activated receptors have been identified as key regulators of glucose and lipid metabolism, because they act as transcription factors that stimulate protein synthesis in a wide variety of processes (energetic metabolism, proliferation, and cellular differentiation), of which have been identified 3 types (alpha, beta/delta, gamma). The thiazolidenediones are compounds that act as agonists of the peroxisome proliferator-activated receptor-gamma increasing the tissues sensibility (muscle, adiposity tissue, and liver) to the insulin action; that is why they are used nowadays in treatment of type 2 diabetes mellitus. These drugs produce several of adverse effects, such as weight increased, edema, anemia, pulmonary edema, and congestive cardiac failure. Even their use have been related for some studies to an increased in the myocardium infarct risk; this correlation has not been a strong determinant to remove them from the market. |
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Authors:
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Valmore Bermúdez; Freddy Finol; Nailyn Parra; Maria Parra; Adriana Pérez; Lianny Peñaranda; Daviel Vílchez; Joselyn Rojas; Nailet Arráiz; Manuel Velasco |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of therapeutics Volume: 17 ISSN: 1536-3686 ISO Abbreviation: Am J Ther Publication Date: 2010 May-Jun |
Date Detail:
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Created Date: 2010-05-18 Completed Date: 2010-08-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9441347 Medline TA: Am J Ther Country: United States |
Other Details:
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Languages: eng Pagination: 274-83 Citation Subset: IM |
Affiliation:
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Endocrine and Metabolic Diseases Research Center, University of Zulia, School of Medicine, Maracaibo, Venezuela. valmore@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Glucose
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metabolism Diabetes Mellitus, Type 2 / drug therapy*, physiopathology Humans Hypoglycemic Agents / adverse effects, pharmacology, therapeutic use* Insulin / secretion Insulin Resistance Lipid Metabolism / drug effects PPAR gamma / agonists* Thiazolidinediones / adverse effects, pharmacology, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Hypoglycemic Agents; 0/PPAR gamma; 0/Thiazolidinediones; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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