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The PPARα Agonist Fenofibrate Reduces Prepulse Inhibition Disruption in a Neurodevelopmental Model of Schizophrenia.
MedLine Citation:
PMID:  22966448     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Oxidative stress has been implicated in neurodevelopmental theories of schizophrenia. Antioxidant Peroxysome Proliferator-Activated Receptors α (PPARα) agonist fenofibrate has neuroprotective properties and could reverse early preclinical infringements that could trigger the illness. We have evaluated the neuroprotective interest of fenofibrate in a neurodevelopmental rat model of schizophrenia. The oxidative lesion induced by Kainic Acid (KA) injection at postnatal day (PND) 7 has previously been reported to disrupt Prepulse Inhibition (PPI) at PND56 but not at PND35. In 4 groups of 15 male rats each, KN (KA-PND7 + normal postweaning food), KF (KA-PND7 + fenofibrate 0.2% food), ON (saline-PND7 + normal food), and OF (saline + fenofibrate food), PPI was recorded at PND35 and PND56. Three levels of prepulse were used: 73 dB, 76 dB, and 82 dB for a pulse at 120 dB. Four PPI scores were analyzed: PPI73, PPI76, PPI82, and mean PPI (PPIm). Two-way ANOVAs were used to evaluate the effects of both factors (KA + fenofibrate), and, in case of significant results, intergroup Student's t-tests were performed. We notably found a significant difference (P < 0.05) in PPIm between groups KN and KF at PND56, which supposes that fenofibrate could be worthy of interest for early neuroprotection in schizophrenia.
Benjamin Rolland; Kevin Marche; Olivier Cottencin; Régis Bordet
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Publication Detail:
Type:  Journal Article     Date:  2012-05-15
Journal Detail:
Title:  Schizophrenia research and treatment     Volume:  2012     ISSN:  2090-2093     ISO Abbreviation:  Schizophr Res Treatment     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-11     Completed Date:  2012-09-12     Revised Date:  2013-04-02    
Medline Journal Info:
Nlm Unique ID:  101576450     Medline TA:  Schizophr Res Treatment     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  839853     Citation Subset:  -    
Département de Pharmacologie Médicale, EA 1046, Université Lille Nord de France, 1 place de Verdun, 59000 Lille, France.
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