| PP13 as a marker of pre-eclampsia: A two platform comparison study. | |
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MedLine Citation:
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PMID: 21257081 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the role of PP13 as a marker for pre-eclampsia (PE) by comparing two different immunoassay platforms. METHODS: In this case-control study, first-trimester serum samples from 195 normal pregnancies and 37 pregnancies with PE were analysed for PP13 by using a manual DTL ELISA and the AutoDELFIA(®) platform. RESULTS: Levels of PP13 in first-trimester pregnancies increased with gestational age in controls and pre-eclampsia cases using both methods of analysis, but at different rates. PP13 levels were decreased in women with PE. Levels of the marker are found to be more reduced in PE cases when measured using the DTL ELISA compared to AutoDELFIA(®). CONCLUSION: Further studies are needed to compare the performance of the DTL ELISA and the AutoDELFIA(®) PP13 assays in terms of reproducibility, robustness and clinical performance in predicting pre-eclampsia. |
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Authors:
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N J Cowans; A Stamatopoulou; A Khalil; K Spencer |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Placenta Volume: 32 Suppl ISSN: 1532-3102 ISO Abbreviation: Placenta Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8006349 Medline TA: Placenta Country: England |
Other Details:
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Languages: eng Pagination: S37-41 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Prenatal Research Unit, Clinical Biochemistry Department, King George Hospital, Goodmayes IG3 8YB, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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