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PP13 and PAPP-A in the First and Second Trimesters: Predictive Factors for Preeclampsia?
MedLine Citation:
PMID:  22778981     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Background. Preeclampsia affects 5-6% of all pregnancies. Predictive factors of preeclampsia can be helpful in early diagnosis of this disease. In this study the predictive values of biochemical markers placenta protein 13 (PP13) and pregnancy-associated plasma protein A (PAPP-A) have been assessed in early diagnosis of preeclampsia. Methods. This case-control study was conducted on 1500 women who presented to a healthcare center of Sari, Iran, between 2010 and 2011. Blood samples were drawn in weeks 11-13 and 24-28 of pregnancy. Of them who developed preeclampsia were considered as case group. A control group consisted of similar women regarding mean age, body mass index (BMI), and pregnancy age. PAPP-A and PP13 serum levels were measured. Data were analyzed using proper statistical tests. Results. PAPP-A and PP13 serum levels were significantly lower in both the first and second trimesters in women who developed preeclampsia (P < 0.001). The cumulative value of all four variables with cut-off point of 238.5 has sensitivity, specificity of 91.0%, and undercurve surface of 0.968 which is the most diagnostic value for preeclampsia. Conclusion. It is possible to advantage measuring of PAPP-A and PP13 in the first and second trimesters especially their cumulative values in both trimesters for prediction of the incidence of preeclampsia.
Authors:
Narges Moslemi Zadeh; Farshad Naghshvar; Sepideh Peyvandi; Parand Gheshlaghi; Sara Ehetshami
Publication Detail:
Type:  Journal Article     Date:  2012-06-18
Journal Detail:
Title:  ISRN obstetrics and gynecology     Volume:  2012     ISSN:  2090-4444     ISO Abbreviation:  ISRN Obstet Gynecol     Publication Date:  2012  
Date Detail:
Created Date:  2012-07-10     Completed Date:  2012-08-23     Revised Date:  2013-03-11    
Medline Journal Info:
Nlm Unique ID:  101558763     Medline TA:  ISRN Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  263871     Citation Subset:  -    
Affiliation:
OB/GYN Department, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran.
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