| POTE protein, a cancer-testis antigen, is highly expressed in spermatids in human testis and is associated with apoptotic cells. | |
| | |
MedLine Citation:
|
PMID: 22234308 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The POTE gene family encodes very closely related proteins that are highly expressed in testis and in many cancers. Recent studies indicate that the POTE proteins have a pro-apoptotic function. To examine if POTE is associated with cells that are undergoing apoptosis in testis, we determined the cellular location of POTE and of Cleaved Caspase-3 in testicular tissues from 26 azoospermic men. We found intense expression of POTE in round spermatids that are undergoing apoptosis, which are positive for Cleaved Caspase-3. This study suggests POTE may have a role in apoptosis in the human testis. |
| | |
Authors:
|
Tapan K Bera; Dawn A Walker; Richard J Sherins; Ira Pastan |
Related Documents
:
|
11205068 - Glue solvent inhalation impairs host resistance to mycobacterium bovis-induced infectio... 9723778 - Antigen-specific lymphocytes enhance nitric oxide production in mycobacterium bovis bcg... 21766178 - Induction of apoptosis in murine leukemia by diarylheptanoids from curcuma comosa roxb. 17330188 - Sarcoidosis--immunopathogenetic concepts. 17059508 - Interleukin-4 inhibits cyclo-oxygenase-2 expression and prostaglandin e production by h... 20802348 - Stromal macrophage expressing cd204 is associated with tumor aggressiveness in lung ade... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-3 |
Journal Detail:
|
Title: Biochemical and biophysical research communications Volume: - ISSN: 1090-2104 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012. Published by Elsevier Inc. |
Affiliation:
|
Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Human hepatitis B viral e antigen and its precursor P20 inhibit T lymphocyte proliferation.
Next Document: Macrophage expression of LRP1, a receptor for apoptotic cells and unopsonized erythrocytes, can be r...