| Point: a prescription to decrease left ventricular function. | |
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MedLine Citation:
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PMID: 19751478 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Courage Trial, published in 2007, has significantly reduced the incidence of treating stable angina with angioplasty. The investigators randomized 2297 patients with documented cardiac ischemia to conservative or invasive therapy and concluded that there was no difference in major events during a follow-up of 2.5 to 7 years and that the urge to open the narrowed artery was unjustified. Over the years it has been well documented by myocardial biopsy that repeated ischemic episodes result in replacement of myocardial cells by fibrous tissue, loss of mitochondria, and deterioration of left ventricular function. Ischemic episodes often occur in the absence of angina so that it is impossible to determine whether the therapy is reducing the magnitude or duration of the process. Also, in their study, 32% of the conservatively treated patients crossed over to invasive. The evidence indicated that conservative treatment may result in a progressive decrease in left ventricular function. |
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Authors:
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Myrvin H Ellestad |
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Publication Detail:
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Type: Editorial |
Journal Detail:
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Title: Preventive cardiology Volume: 12 ISSN: 1751-7141 ISO Abbreviation: Prev Cardiol Publication Date: 2009 |
Date Detail:
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Created Date: 2009-09-15 Completed Date: 2010-03-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9813731 Medline TA: Prev Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 169-70 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Wiley Periodicals, Inc. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angina Pectoris
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physiopathology,
therapy Angioplasty, Transluminal, Percutaneous Coronary Hemodynamics Humans Myocardial Ischemia / physiopathology*, therapy Ventricular Function, Left* |
| Comments/Corrections | |
Comment In:
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Prev Cardiol. 2009 Fall;12(4):171-2
[PMID:
19751479
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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