| POEMS syndrome and Waldenström's macroglobulinaemia. | |
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MedLine Citation:
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PMID: 8655693 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 58 year old man presented with a three year history of impotence, night sweats and ankle swelling. On examination, the patient fulfilled the diagnostic criteria for POEMS syndrome, but was unusual in that he also had underlying Waldenström's macroglobulinaemia with IgM kappa paraproteinaemia. The patient was treated with intermittent chlorambucil and made a good recovery. POEMS syndrome has been described in association with osteosclerotic myeloma and Castleman's disease. The paraprotein involved is usually IgG or IgA with lambda light chains. This case indicates that the presence of lambda light chains is not essential for the pathogenesis of POEMS syndrome. It also emphasises the diversity of plasma cell dyscrasias that can manifest as POEMS syndrome. |
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Authors:
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S R Pavord; P T Murphy; V E Mitchell |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of clinical pathology Volume: 49 ISSN: 0021-9746 ISO Abbreviation: J. Clin. Pathol. Publication Date: 1996 Feb |
Date Detail:
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Created Date: 1996-07-31 Completed Date: 1996-07-31 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0376601 Medline TA: J Clin Pathol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 181-2 Citation Subset: AIM; IM |
Affiliation:
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Department of Haematology, Leicester Royal Infirmary. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Humans Immunoglobulin M / blood* Immunoglobulin kappa-Chains / blood* Male Middle Aged POEMS Syndrome / etiology* Paraproteinemias / complications* Waldenstrom Macroglobulinemia / complications* |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin M; 0/Immunoglobulin kappa-Chains |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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