| PNPLA3 polymorphism influences liver fibrosis in unselected patients with type 2 diabetes. | |
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MedLine Citation:
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PMID: 21745307 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Context: Recently, it has been shown that an allele in the adiponutrin (PNPLA3) gene was strongly associated with increased liver fat content (LFC) and liver fibrosis independent of visceral adiposity and insulin resistance. Objective: In this study, we set out to determine whether the PNPLA3 rs738409 polymorphism was associated with liver fibrosis in unselected patients with type 2 diabetes. Design, setting and participants: Two hundred and thirty-four patients with type 2 diabetes were included in this study. Main outcome measures: LFC was evaluated using (1) H-MR spectroscopy; fibrosis was measured using the non-invasive FibroTest(®) . Results: Advanced liver fibrosis (stage F2 or above) was observed in 10.2% of the patients while 149 (63.6%) patients had steatosis. The prevalence of steatosis and fibrosis was higher in minor G allele carriers than that in C allele homozygote carriers (70.3 vs 57.1%; P=0.04 and 14.7 vs 7.5%; P=0.07 respectively). In multivariate analysis, the predictive variables for advanced liver fibrosis were age (≥60) (P=0.005), sex (female) (P=0.004) and rs 738409 PNPLA3 polymorphism (P=0.01); body mass index (BMI) and LFC were not associated with liver fibrosis. Conclusions: This study confirms that in patients with type 2 diabetes who were not selected for liver abnormalities, liver fibrosis was related to the rs738409 polymorphism independent of BMI or LFC. |
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Authors:
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Jean M Petit; Boris Guiu; David Masson; Laurence Duvillard; Valerie Jooste; Perrine Buffier; Benjamin Bouillet; Marie-Claude Brindisi; Isabelle Robin; Philippe Gambert; Bruno Verges; Jean-Pierre Cercueil; Patrick Hillon |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-22 |
Journal Detail:
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Title: Liver international : official journal of the International Association for the Study of the Liver Volume: - ISSN: 1478-3231 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-7-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101160857 Medline TA: Liver Int Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 John Wiley & Sons A/S. |
Affiliation:
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Centre de Recherche, INSERM Unité 866, Université de Bourgogne, CHU du Bocage, Dijon, France Services de diabétologie et endocrinologie, CHU du Bocage, Dijon, France de radiologie, CHU du Bocage, Dijon, France d'hépatologie,CHU du Bocage, Dijon, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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