Document Detail

PNMT inhibition decreases exercise performance in the rat.
MedLine Citation:
PMID:  1523268     Owner:  NLM     Status:  MEDLINE    
The purpose of this investigation was to examine the effect of phenylethanolamine N-methyltransferase (PNMT) inhibition on the regulation of peripheral metabolic and hormonal responses during treadmill exercise in the rat. Changes in plasma catecholamine (epinephrine, norepinephrine, and dopamine), glucagon and glucose, and the glycogen content of the liver and two skeletal muscles were studied in four groups of rats. Two groups of rats were studied at rest: one group had been treated with LY134046, an inhibitor of PNMT, and the second group was treated with physiological saline. A third group treated with LY134046 was studied after treadmill exercise (28 m.min-1 and 8% slope). In this group of rats, exhaustion came after 37.5 +/- 7.9 minutes of exercise. In order to make appropriate comparisons, a fourth group of rats treated with physiological saline was exercised for 37.5 min. Running endurance during the treadmill exercise was thus reduced in LY134046-treated rats. Plasma epinephrine and glucagon concentrations and other metabolic (plasma glucose and gastrocnemius lateralis and superficial vastus lateralis muscles and liver glycogen contents) responses were similar between LY134046- and saline-treated rats at rest and after exercise. These results suggest that PNMT inhibition in epinephrine brain neurons might be the principal factor involved in the LY134046-induced reduction of exercise endurance.
F Trudeau; G R Brisson; F Péronnet
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Physiology & behavior     Volume:  52     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-10-15     Completed Date:  1992-10-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  389-92     Citation Subset:  IM; S    
Ecole de l'activité physique, Université Laurentienne, Sudbury, Ontario, Canada.
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MeSH Terms
Benzazepines / pharmacology
Blood Glucose / metabolism
Catecholamines / blood
Glucagon / blood
Glycogen / metabolism
Liver Glycogen / metabolism
Muscles / drug effects,  metabolism
Phenylethanolamine N-Methyltransferase / antagonists & inhibitors*
Physical Exertion / drug effects*
Rats, Inbred Strains
Reg. No./Substance:
0/Benzazepines; 0/Blood Glucose; 0/Catecholamines; 0/Liver Glycogen; 71274-97-0/LY 134046; 9005-79-2/Glycogen; 9007-92-5/Glucagon; EC N-Methyltransferase

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