| PLGA and PHBV microsphere formulations and solid-state characterization: possible implications for local delivery of fusidic acid for the treatment and prevention of orthopaedic infections. | |
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MedLine Citation:
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PMID: 19384471 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To develop and characterize the solid-state properties of poly(DL-lactic-co-glycolic acid) (PLGA) and poly(3-hydroxybutyric acid-co-3-hydroxyvaleric acid) (PHBV) microspheres for the localized and controlled release of fusidic acid (FA). METHODS: The effects of FA loading and polymer composition on the mean diameter, encapsulation efficiency and FA released from the microspheres were determined. The solid-state and phase separation properties of the microspheres were characterized using DSC, XRPD, Raman spectroscopy, SEM, laser confocal and real time recording of single microspheres formation. RESULTS: Above a loading of 1% (w/w) FA phase separated from PLGA polymer and formed distinct spherical FA-rich amorphous microdomains throughout the PLGA microsphere. For FA-loaded PLGA microspheres, encapsulation efficiency and cumulative release increased with initial drug loading. Similarly, cumulative release from FA-loaded PHBV microspheres was increased by FA loading. After the initial burst release, FA was released from PLGA microspheres much slower compared to PHBV microspheres. CONCLUSIONS: A unique phase separation phenomenon of FA in PLGA but not in PHBV polymers was observed, driven by coalescence of liquid microdroplets of a DCM-FA-rich phase in the forming microsphere. |
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Authors:
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Chiming Yang; David Plackett; David Needham; Helen M Burt |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-04-21 |
Journal Detail:
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Title: Pharmaceutical research Volume: 26 ISSN: 1573-904X ISO Abbreviation: Pharm. Res. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-02 Completed Date: 2009-08-17 Revised Date: 2010-12-03 |
Medline Journal Info:
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Nlm Unique ID: 8406521 Medline TA: Pharm Res Country: United States |
Other Details:
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Languages: eng Pagination: 1644-56 Citation Subset: IM |
Affiliation:
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Faculty of Pharmaceutical Sciences, The University of British Columbia, 2146 East Mall, Vancouver BCV6T1Z3, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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chemistry* Calorimetry, Differential Scanning Delayed-Action Preparations / chemistry* Fusidic Acid / chemistry* Glycolates / chemistry* Kinetics Microspheres* Particle Size Phase Transition Polyesters / chemistry* Powder Diffraction Surface Properties X-Ray Diffraction |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Delayed-Action Preparations; 0/Glycolates; 0/Polyesters; 0/poly(3-hydroxybutyrate)-co-(3-hydroxyvalerate); 0/polylactic acid-polyglycolic acid copolymer; 6990-06-3/Fusidic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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