| PLGA-(L-Asp-alt-diol)(x)-PLGAs with different contents of pendant amino groups: synthesis and characterization. | |
| | |
MedLine Citation:
|
PMID: 15991217 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A series of novel biodegradable multi-block copolymers PLGA-(L-Asp-alt-diol)(x)-PLGA with pendant amino groups was synthesized by ring-opening polymerization of D,L-lactide/glycolide(D,L-LA/GA) (75/25) using poly(N-Cbz-L-Asp-alt-diol)s as macroinitiator and stannous octoate as catalyst, in which the N-Cbz-L-Asp represents N-carbobenzyloxy-L-aspartic acid and diols are ethylene glycol, triethylene glycol, PEG200, and PEG600, respectively. Their structures and properties were characterized by FTIR, (1)H NMR, DSC, GPC, and elemental analysis (EA). The contents of the L-Asp unit in the copolymers were increased from 12.9 to 79.3 mmol.g(-1) with decreasing the chain length of the diol, while the glass transition temperatures of the copolymers were decreased from 27.1 to 11.7 degrees C with increasing the chain length of the diol. Thus, the results in this study provide a way to prepare biomaterials with different L-Asp unit densities or different number of bioactive sites as well as different properties through adjusting the chain length of the diol. Synthesis of PLGA-(N-Cbz-L-Asp-alt-diol)(x)-PLGA copolymers. |
| | |
Authors:
|
Jie Zhao; Daping Quan; Kairong Liao; Qing Wu |
Related Documents
:
|
5861707 - The effects of solvent environment on the optical rotatory dispersion parameters of pol... 17761187 - Steady surface modification of polydimethylsiloxane microchannel and its application in... 16327137 - Photographic appraisal of crystal lattice growth technique. 10842137 - In vitro dentinal surface reaction of 9.5% buffered hydrofluoric acid in repair of cera... 21858317 - Spirocyclic systems derived from pyroglutamic acid. 2001377 - Metabolic origin of urinary 3-hydroxy dicarboxylic acids. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Macromolecular bioscience Volume: 5 ISSN: 1616-5187 ISO Abbreviation: Macromol Biosci Publication Date: 2005 Jul |
Date Detail:
|
Created Date: 2005-07-18 Completed Date: 2005-12-05 Revised Date: 2009-11-03 |
Medline Journal Info:
|
Nlm Unique ID: 101135941 Medline TA: Macromol Biosci Country: Germany |
Other Details:
|
Languages: eng Pagination: 636-43 Citation Subset: IM |
Affiliation:
|
Institute of Polymer Science, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Asparagine
/
chemistry* Biocompatible Materials / chemical synthesis, chemistry* Lactic Acid / chemical synthesis, chemistry* Molecular Structure Polyglycolic Acid / chemical synthesis, chemistry* Polymers / chemical synthesis, chemistry* |
| Chemical | |
Reg. No./Substance:
|
0/Biocompatible Materials; 0/Polymers; 0/polylactic acid-polyglycolic acid copolymer; 26009-03-0/Polyglycolic Acid; 50-21-5/Lactic Acid; 7006-34-0/Asparagine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: In vitro enzymatic degradation of nanoparticles prepared from hydrophobically-modified poly(gamma-gl...
Next Document: Does "excessive" or "compulsive" best describe exercise as a symptom of bulimia nervosa?