Document Detail

PLAIDD, a type II death domain protein that interacts with p75 neurotrophin receptor.
MedLine Citation:
PMID:  12095158     Owner:  NLM     Status:  MEDLINE    
We describe the cloning and characterization of a rat single transmembrane protein that is homologous to the common neurotrophin receptor p75NTR in its death domain and the transmembrane region but dissimilar outside these regions. We have dubbed this protein PLAIDD, for p75-like apoptosis-inducing death domain protein. PLAIDD messenger RNA, which is ubiquitously distributed, is highly expressed in the embryo, but downregulated in adult tissues. Alternative splicing within the extracellular region of PLAIDD generates four RNA species, but only two of them are translated, PLAIDD_L and PLAIDD_S (long and short isoforms, respectively). While the amino acid sequence of the intracellular region of PLAIDD displays 41% identity with the intracellular region of p75NTR, the extracellular region of PLAIDD does not reveal any homology with p75NTR. Overexpression of each isoform of PLAIDD led to cytotoxicity in superior cervical ganglion neurons and in human embryonic kidney 293T cells. Both isoforms of PLAIDD could be co-immunoprecipitated with p75NTR, suggesting an interaction between these molecules.
Harald Frankowski; Susana Castro-Obregon; Gabriel del Rio; Rammohan V Rao; Dale E Bredesen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuromolecular medicine     Volume:  1     ISSN:  1535-1084     ISO Abbreviation:  Neuromolecular Med.     Publication Date:  2002  
Date Detail:
Created Date:  2002-07-03     Completed Date:  2003-01-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  101135365     Medline TA:  Neuromolecular Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  153-70     Citation Subset:  IM    
Buck Institute for Age Research, Novato, CA 94945-1400, USA.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AF497263;  AF497264;  AI437140;  AI629342
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MeSH Terms
Animals, Newborn
Apoptosis / physiology*
Apoptosis Regulatory Proteins
Carrier Proteins / genetics,  isolation & purification*
Cell Membrane / metabolism
Cells, Cultured
Gene Expression / physiology
Membrane Proteins / genetics,  isolation & purification*
Molecular Sequence Data
Protein Biosynthesis / genetics
Protein Structure, Tertiary / genetics
RNA, Messenger / genetics,  isolation & purification
Receptor, Nerve Growth Factor
Receptors, Nerve Growth Factor / metabolism*
Sequence Homology, Amino Acid
Sequence Homology, Nucleic Acid
Grant Support
Reg. No./Substance:
0/Apoptosis Regulatory Proteins; 0/Carrier Proteins; 0/Membrane Proteins; 0/PLAIDD protein, rat; 0/RNA, Messenger; 0/Receptor, Nerve Growth Factor; 0/Receptors, Nerve Growth Factor

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