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PIVKA-II plasma levels as markers of subclinical vitamin K deficiency in term infants.
MedLine Citation:
PMID:  22280352     Owner:  NLM     Status:  Publisher    
Abstract Background: As the vitamin K content of human milk is low and the newborn infant's stores of vitamin K are small, vitamin K deficiency with hemorrhage in the newborn is a worldwide problem. Proteins Induced by Vitamin K Absence (PIVKA-II) are the inactive under-?-carboxylated forms of vitamin K-dependent clotting factors and they could be useful in predicting subclinical vitamin K deficiency (VKD). Objectives: To demonstrate that PIVKA-II are earlier markers of subclinical VKD than Prothrombin time (PT) in exclusively breast fed newborns. Methods: A prospective, controlled, randomized study, including 53 term newborns receiving vitamin K prophylaxis (0.5 mg im) at birth, was performed. At 30 days newborns were divided into three groups (G) receiving respectively: 25 ?g/die of vitamin K (G I), 12 ?g/die (G II) or placebo (G III). PIVKA II and PT were measured on 30th and 90th days of life. Results: G III and GII showed a significant increase in PIVKA II from 30 to 90 days of life respectively from 2.6 to 4.7 (p = 0.001) and from 2.3 to 3.5 (p<0.001). No significant changes were found in GI. PT showed no significant changes among groups. Conclusions: PT is a less sensitive marker than PIVKA II. Oral supplementation with 25 ?g/die avoids an increase of PIVKA II. Despite increased PIVKA II do not mean an impending occurrence of bleeding, they highlight a subclinical VKD and its relative risk.
Dituri F; Buonocore G; Pietravalle A; Naddeo F; Cortesi M; Pasqualetti P; Tataranno Ml; Agostino R
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-26
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Maternal and Child Health, S. Giovanni Calibita Hospital, Fatebenefratelli, Rome.
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