| PINing down the origin of prostate cancer. | |
| | |
MedLine Citation:
|
PMID: 20686176 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
The epithelium that lines the surface of prostate glands contains several cell types, including luminal secretory cells and basal cells of unclear function. Despite the fact that prostate tumors contain cells with a luminal phenotype and lack basal cells, a recent report indicates that the cell of origin for human prostate cancer is a basal cell and not a luminal cell. In contrast, another study indicates the reverse. It is possible that both basal and luminal stem/progenitor cells may independently give rise to prostate cancer; a comparison of the molecular signatures of the target cells of transformation with those of prostate tumors may aid in predicting the phenotypes of tumors with aggressive characteristics. |
| | |
Authors:
|
David Moscatelli; E Lynette Wilson |
Related Documents
:
|
18632636 - Extracellular redox state regulates features associated with prostate cancer cell invas... 8157936 - Immunocytochemical localization of human 5 alpha-reductase 2 with polyclonal antibodies... 1396346 - Estrogen synthesis by osteoblast cell lines. 12839976 - Rna interference-mediated silencing of the fatty acid synthase gene attenuates growth a... 20493256 - Novel, orally active selective progesterone receptor modulator cp8947 inhibits leiomyom... 6969156 - The effect of the plant lectins phytohaemagglutinin and concanavalin a on human t cell ... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Science translational medicine Volume: 2 ISSN: 1946-6242 ISO Abbreviation: Sci Transl Med Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-08-05 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101505086 Medline TA: Sci Transl Med Country: United States |
Other Details:
|
Languages: eng Pagination: 43ps38 Citation Subset: IM |
Affiliation:
|
Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
| Grant Support | |
ID/Acronym/Agency:
|
AG34305/AG/NIA NIH HHS; CA132641/CA/NCI NIH HHS; R21 AG034305-01A1/AG/NIA NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cardiac hypertrophy, low blood pressure, and low aldosterone levels in mice devoid of the three circ...
Next Document: A microbe-dependent viral key to Crohn's box.