Document Detail

PIII and derived PII analysis in a patient with retinal dysfunction with supernormal scotopic ERG.
MedLine Citation:
PMID:  16328930     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To present electroretinographic (ERG) findings in a patient with retinal dysfunction with supernormal scotopic ERG, and to analyze rod and cone PIII components and rod inner nuclear layer (derived PII) responses. PATIENT: A Japanese 11-year-old girl complained of poor visual acuity. There was no parental consanguinity in her family. The corrected visual acuity was 0.7 in both eyes. No abnormal finding was observed in both fundi. METHODS: The patient underwent full-field ERGs. Rod and cone a-waves were analyzed using photoreceptor models. The derived PII responses were analyzed using a technique described by Hood and Birch. RESULTS: In the photopic ERG, responses to single flash and 30-Hz flicker were attenuated. In the scotopic ERG, b-wave was supernormal in amplitude in response to intense flashes, but smaller than normal and markedly delayed over a lower range of flash intensities. By the PIII analysis, phototransductions (values of S) of both rod and cone were remarkably decreased. The derived PII responses for this patient were larger than the responses for normal subjects, and the onset of the PII responses in this patient are significantly delayed compared to those in normal subjects. CONCLUSIONS: The ophthalmological findings in this patient are consistent with previous publications of this disease. Although it has been reported that the sites of disease action were beyond the outer segment (values of S were within the normal range), our results suggest that photoreceptors could be involved in sites of disease action in at least some patients with this disease.
Naoyuki Tanimoto; Tomoaki Usui; Mikio Ichibe; Mineo Takagi; Shigeru Hasegawa; Haruki Abe
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Documenta ophthalmologica. Advances in ophthalmology     Volume:  110     ISSN:  0012-4486     ISO Abbreviation:  Doc Ophthalmol     Publication Date:    2005 Mar-May
Date Detail:
Created Date:  2005-12-05     Completed Date:  2006-07-11     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370667     Medline TA:  Doc Ophthalmol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  219-26     Citation Subset:  IM    
Division of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Niigata University, 1-757, Asahimachi, Niigata, 951-8510, Japan.
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MeSH Terms
Dark Adaptation / physiology*
Photoreceptor Cells, Vertebrate / physiology
Retinal Diseases / physiopathology*
Severity of Illness Index
Vision, Ocular / physiology*

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