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PICS-ure this: prosenescence therapy?
MedLine Citation:
PMID:  20227036     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Senescence is increasingly recognized as a critical feature of mammalian cells to suppress tumorigenesis, acting together with cell death programs. Whether senescence, like programmed cell death, can be exploited therapeutically has been unclear. Pandolfi and coworkers now propose that PTEN-loss-induced cellular senescence (PICS) may be triggered in vivo for therapy.
Authors:
Daniel S Peeper
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer cell     Volume:  17     ISSN:  1878-3686     ISO Abbreviation:  Cancer Cell     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-15     Completed Date:  2010-06-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101130617     Medline TA:  Cancer Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  219-20     Citation Subset:  -    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Affiliation:
The Netherlands Cancer Institute, Division of Molecular Genetics, 1066 CX Amsterdam, the Netherlands. d.peeper@nki.nl
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