| PIASy interacts with p73alpha and regulates cell cycle in HEK293 cells. | |
| | |
MedLine Citation:
|
PMID: 20471636 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
p73, a recently described member of the p53 family of transcription factors, undergoes a number of posttranslational modifications, inducing cell cycle arrest and apoptosis. In the present study, we demonstrate that PIASy, a member of the PIAS SUMO-ligase family, interacts with p73alpha, and that PIASy-mediated sumoylation promotes proteasomal degradation of p73alpha. PIASy overexpression inhibits p73alpha-mediated transcription of p21, with a reduction of cells in G1 and cell cycle reentry. These results suggest that PIASy plays an important role in regulation of p73alpha transcriptional activity and is also a regulator of the cell cycle machinery. |
| | |
Authors:
|
Chao Zhang; Xia Yuan; Ling Yue; Jin Fu; Lan Luo; Zhimin Yin |
Related Documents
:
|
17571276 - The complex p25/cdk5 kinase in neurofibrillary degeneration and neuronal death: the mis... 14673156 - Mtor controls cell cycle progression through its cell growth effectors s6k1 and 4e-bp1/... 12414986 - Hedgehogs tryst with the cell cycle. 17015676 - Cutting edge: abortive proliferation of cd46-induced tr1-like cells due to a defective ... 15513496 - Laser-induced thermal stress and the heat shock response in neural cells. 9272956 - Zebrafish vasa homologue rna is localized to the cleavage planes of 2- and 4-cell-stage... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-18 |
Journal Detail:
|
Title: Cellular immunology Volume: 263 ISSN: 1090-2163 ISO Abbreviation: Cell. Immunol. Publication Date: 2010 |
Date Detail:
|
Created Date: 2010-06-10 Completed Date: 2010-07-02 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 1246405 Medline TA: Cell Immunol Country: United States |
Other Details:
|
Languages: eng Pagination: 235-40 Citation Subset: IM |
Copyright Information:
|
Copyright (c) 2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210046, PR China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cell Cycle
/
physiology* Cell Line DNA-Binding Proteins / metabolism* Gene Expression Humans Immunoblotting Nuclear Proteins / metabolism* Protein Binding Protein Inhibitors of Activated STAT / metabolism* Protein Processing, Post-Translational* Reverse Transcriptase Polymerase Chain Reaction Small Ubiquitin-Related Modifier Proteins / metabolism Tumor Suppressor Proteins / metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/DNA-Binding Proteins; 0/Nuclear Proteins; 0/Protein Inhibitors of Activated STAT; 0/Small Ubiquitin-Related Modifier Proteins; 0/Tumor Suppressor Proteins; 0/tumor suppressor protein p73 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Synthesis and antimicrobial activity of some new N-glycosides of 2-thioxo-4-thiazolidinone derivativ...
Next Document: Smart medical environment at the point of care: Auto-tracking clinical interventions at the bed side...