Document Detail


PI3K and Chemotaxis: A Priming Issue?
MedLine Citation:
PMID:  21521877     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Although the spatiotemporal activation of phosphoinositide 3-kinases (PI3Ks) at the leading edge of chemotaxing cells represents a key marker of polarity, both Dictyostelium discoideum and neutrophils lacking measurable PI3K activity can still migrate directionally under certain conditions. Evidence from various papers suggests that the differentiation state of cells or their priming status can consolidate otherwise contradictory findings.
Authors:
Philippe V Afonso; Carole A Parent
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Publication Detail:
Type:  Journal Article     Date:  2011-04-26
Journal Detail:
Title:  Science signaling     Volume:  4     ISSN:  1937-9145     ISO Abbreviation:  Sci Signal     Publication Date:  2011  
Date Detail:
Created Date:  2011-04-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101465400     Medline TA:  Sci Signal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  pe22     Citation Subset:  IM    
Affiliation:
Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
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