Document Detail


PGE2: metabolic effects in healthy volunteers.
MedLine Citation:
PMID:  734229     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Some metabolic and haemodynamic responses to intravenous prostaglandin (PG) were studied in five healthy male volunteers, aged 27-40. Subjects, who fasted overnight, rested supine for for 30 min before any measurements were made. Control pulse rate and arterial blood pressure were recorded and 20ml venous blood drawn for analysis. Intravenous infusion of PGE2 5 microgram/min then began and was continued for 15 min; the dose was then increased to 7.5 microgram/min. Measurements were made during the infusion at 15 and 30 min and also 15 min after infusion was stopped. Pulse rate increased but blood pressure was unaffected by the infusion. Glycerol and FFA levels rose, whereas lactate and pyruvate levels fell during the infusion. The rise in glycerol level was significant at 30 min. The changes recorded were slight in clinical terms but the study provides a baseline for the screening of other PG analogues.
Authors:
W P Leary; A C Asmal; J Carboni; S Wattrus
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Research communications in chemical pathology and pharmacology     Volume:  22     ISSN:  0034-5164     ISO Abbreviation:  Res. Commun. Chem. Pathol. Pharmacol.     Publication Date:  1978 Dec 
Date Detail:
Created Date:  1979-03-24     Completed Date:  1979-03-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0244734     Medline TA:  Res Commun Chem Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  493-500     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Glucose / metabolism
Blood Pressure / drug effects
Hemodynamics / drug effects*
Humans
Lipids / blood
Male
Metabolism / drug effects*
Prostaglandins E / blood,  pharmacology*
Pulse / drug effects
Time Factors
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Lipids; 0/Prostaglandins E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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