| A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. | |
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MedLine Citation:
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PMID: 22237023 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Exercise benefits a variety of organ systems in mammals, and some of the best-recognized effects of exercise on muscle are mediated by the transcriptional co-activator PPAR-γ co-activator-1 α (PGC1-α). Here we show in mouse that PGC1-α expression in muscle stimulates an increase in expression of FNDC5, a membrane protein that is cleaved and secreted as a newly identified hormone, irisin. Irisin acts on white adipose cells in culture and in vivo to stimulate UCP1 expression and a broad program of brown-fat-like development. Irisin is induced with exercise in mice and humans, and mildly increased irisin levels in the blood cause an increase in energy expenditure in mice with no changes in movement or food intake. This results in improvements in obesity and glucose homeostasis. Irisin could be therapeutic for human metabolic disease and other disorders that are improved with exercise. |
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Authors:
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Pontus Boström; Jun Wu; Mark P Jedrychowski; Anisha Korde; Li Ye; James C Lo; Kyle A Rasbach; Elisabeth Almer Boström; Jang Hyun Choi; Jonathan Z Long; Shingo Kajimura; Maria Cristina Zingaretti; Birgitte F Vind; Hua Tu; Saverio Cinti; Kurt Højlund; Steven P Gygi; Bruce M Spiegelman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-01-11 |
Journal Detail:
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Title: Nature Volume: 481 ISSN: 1476-4687 ISO Abbreviation: Nature Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-27 Completed Date: 2012-03-02 Revised Date: 2012-04-25 |
Medline Journal Info:
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Nlm Unique ID: 0410462 Medline TA: Nature Country: England |
Other Details:
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Languages: eng Pagination: 463-8 Citation Subset: IM |
Affiliation:
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Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipocytes
/
cytology,
drug effects,
metabolism Adipose Tissue, Brown / cytology*, drug effects, metabolism Adipose Tissue, White / cytology*, drug effects, metabolism Animals Cell Respiration / drug effects Cells, Cultured Culture Media, Conditioned / pharmacology Energy Metabolism / drug effects, genetics, physiology Exercise / physiology Gene Expression Regulation / drug effects, genetics Hormones / metabolism, secretion Humans Insulin Resistance / physiology Intracellular Signaling Peptides and Proteins / genetics, metabolism Ion Channels / metabolism Mice Mice, Inbred BALB C Mice, Transgenic Mitochondrial Proteins / metabolism Models, Animal Muscle Cells / metabolism Obesity / blood, chemically induced, prevention & control Physical Conditioning, Animal / physiology Plasma / chemistry Subcutaneous Fat / cytology, drug effects, metabolism Thermogenesis* / drug effects, genetics Trans-Activators / deficiency, genetics, metabolism*, secretion |
| Grant Support | |
ID/Acronym/Agency:
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DK31405/DK/NIDDK NIH HHS; DK54477/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Culture Media, Conditioned; 0/Hormones; 0/Intracellular Signaling Peptides and Proteins; 0/Ion Channels; 0/Mitochondrial Proteins; 0/Ppargc1a protein, mouse; 0/Trans-Activators; 0/mitochondrial uncoupling protein |
| Comments/Corrections | |
Comment In:
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Cell Metab. 2012 Mar 7;15(3):277-8
[PMID:
22405065
]
Nat Rev Endocrinol. 2012 Apr;8(4):195 [PMID: 22290362 ] Nat Rev Drug Discov. 2012 Mar;11(3):189 [PMID: 22338642 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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