| The PGC-1 cascade as a therapeutic target for heart failure. | |
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MedLine Citation:
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PMID: 20888832 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The PPARγ coactivator-1 (PGC-1) family of transcriptional coactivators, together with estrogen related receptors (ERRs), plays a key role in regulating genes involved in myocardial fuel metabolism and cardiac function. Increasing evidence implicates dysregulation of this transcriptional regulatory circuit in the metabolic and functional disturbances that presage heart failure due to common diseases such as hypertension and diabetes. Accordingly, the PGC-1/ERR axis is a plausible candidate therapeutic target for novel therapeutics aimed at reversing the energy metabolic disturbances that contribute to heart failure. This review describes the biologic actions of the PGC-1 and ERR cascade and summarizes the evidence that dysregulation of this transcriptional regulatory circuit contributes to heart failure. Potential strategies to modulate this target pathway are reviewed. This article is part of a special issue entitled "Key Signaling Molecules in Hypertrophy and Heart Failure." |
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Authors:
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Joel Schilling; Daniel P Kelly |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2010-10-01 |
Journal Detail:
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Title: Journal of molecular and cellular cardiology Volume: 51 ISSN: 1095-8584 ISO Abbreviation: J. Mol. Cell. Cardiol. Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-09-19 Completed Date: 2012-01-06 Revised Date: 2013-02-08 |
Medline Journal Info:
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Nlm Unique ID: 0262322 Medline TA: J Mol Cell Cardiol Country: England |
Other Details:
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Languages: eng Pagination: 578-83 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, MO, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Gene Expression Regulation Gene Regulatory Networks Heart / physiopathology Heart Failure / drug therapy*, metabolism, physiopathology Humans Molecular Targeted Therapy Myocardium / metabolism Receptors, Estrogen / metabolism Signal Transduction / drug effects* Transcription Factors / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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DK45416/DK/NIDDK NIH HHS; HL058493/HL/NHLBI NIH HHS; K08 HL098373/HL/NHLBI NIH HHS; K08 HL098373-02/HL/NHLBI NIH HHS; K08 HL098373-03/HL/NHLBI NIH HHS; KO8 22-3040-53603//PHS HHS; R01 DK045416-17/DK/NIDDK NIH HHS; R01 HL058493-14/HL/NHLBI NIH HHS; R01 HL101189-03/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Estrogen; 0/Transcription Factors; 0/peroxisome-proliferator-activated receptor-gamma coactivator-1 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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