| A PET study of stimulus- and task-induced semantic processing. | |
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MedLine Citation:
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PMID: 11906233 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To investigate the neural correlates of semantic processing, previous functional imaging studies have used semantic decision and generation tasks. However, in addition to activating semantic associations these tasks also involve executive functions that are not specific to semantics. The study reported in this paper aims to dissociate brain activity due to stimulus-driven semantic associations and task-induced semantic and executive processing by using repetition and semantic decision on auditorily presented words in a cognitive conjunction design. The left posterior inferior temporal, inferior frontal (BA 44/45), and medial orbital gyri were activated by both tasks, suggesting a general role in stimulus-driven semantic and phonological processing. In addition, semantic decision increased activation in (i) left ventral inferior frontal cortex (BA 47), right cerebellum, and paracingulate, which have all previously been implicated in executive functions, and (ii) a ventral region in the left anterior temporal pole which is commonly affected in patients with semantic impairments. We attribute activation in this area to the effortful linkage of semantic features. Thus, our study replicated the functional dissociation between dorsal and ventral regions of the left inferior frontal cortex. Moreover, it also dissociated the semantic functions of the left posterior inferior temporal gyrus and anterior temporal pole: The posterior region subserves stimulus-driven activation of semantic associations and the left anterior region is involved in task-induced association of semantic information. |
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Authors:
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U Noppeney; C J Price |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: NeuroImage Volume: 15 ISSN: 1053-8119 ISO Abbreviation: Neuroimage Publication Date: 2002 Apr |
Date Detail:
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Created Date: 2002-03-21 Completed Date: 2002-05-30 Revised Date: 2010-05-20 |
Medline Journal Info:
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Nlm Unique ID: 9215515 Medline TA: Neuroimage Country: United States |
Other Details:
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Languages: eng Pagination: 927-35 Citation Subset: IM |
Copyright Information:
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(C)2002 Elsevier Science (USA). |
Affiliation:
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Wellcome Department of Cognitive Neurology, University College London, 12 Queen Square, London WC1N 3BG, United Kingdom. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Attention / physiology* Brain / physiology, radionuclide imaging Brain Mapping Cerebral Cortex / physiology*, radionuclide imaging Decision Making / physiology* Dominance, Cerebral / physiology Female Frontal Lobe / physiology, radionuclide imaging Humans Image Processing, Computer-Assisted Imaging, Three-Dimensional Male Neural Pathways / physiology, radionuclide imaging Paired-Associate Learning / physiology Phonetics Problem Solving Semantics* Speech Perception / physiology* Temporal Lobe / physiology, radionuclide imaging Tomography, Emission-Computed* |
| Grant Support | |
ID/Acronym/Agency:
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051067//Wellcome Trust |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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