| PET scans in the staging of lymphoma: current status. | |
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MedLine Citation:
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PMID: 14530496 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Positron emission tomography (PET) is a novel functional imaging technique that provides several inherent advantages over conventional nuclear scintigraphy. Several studies have suggested a role for PET using the positron emitter fluorine-18 in the diagnosis and follow-up of patients with lymphoma. This review summarizes the existing data evaluating the role of 2-fluoro-2-deoxy-D-glucose (FDG)-PET in both the staging and follow-up of patients with lymphoma. Most studies of PET involve patients with either Hodgkin's disease or diffuse large B-cell non-Hodgkin's lymphoma. PET detects more disease sites above and below the diaphragm on staging of lymphoma than gallium scintigraphy and may have particular utility in the evaluation of the spleen. Moreover, persistently positive PET scans during and after chemotherapy appear to have a high sensitivity for predicting subsequent relapse. A negative PET scan at the end of therapy provides very favorable prognostic information. Persistently positive PET scans at the end of therapy warrant close follow-up or additional diagnostic procedures, since some of those patients may remain in prolonged remission. Clearly, additional studies, including prospective blinded trials and cost-effectiveness analyses, are warranted to determine which subsets of patients with lymphoma ultimately will benefit from this modality. |
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Authors:
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Jonathan W Friedberg; Vaseem Chengazi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: The oncologist Volume: 8 ISSN: 1083-7159 ISO Abbreviation: Oncologist Publication Date: 2003 |
Date Detail:
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Created Date: 2003-10-07 Completed Date: 2004-02-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9607837 Medline TA: Oncologist Country: United States |
Other Details:
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Languages: eng Pagination: 438-47 Citation Subset: IM |
Affiliation:
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Lymphoma Program, James P. Wilmot Cancer Center, University of Rochester, Rochester, New York 14642, USA. Jonathan.Friedbueg@urmc.rochester.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Fluorine Radioisotopes
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diagnostic use Fluorodeoxyglucose F18 / diagnostic use Humans Lymphoma / pathology, radionuclide imaging* Neoplasm Staging Predictive Value of Tests Radiopharmaceuticals / diagnostic use Tomography, Emission-Computed |
| Chemical | |
Reg. No./Substance:
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0/Fluorine Radioisotopes; 0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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