Document Detail


PET measurement of the coronary flow reserve and microcirculatory function.
MedLine Citation:
PMID:  10609158     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This review article discusses some of the potentially beneficial effects of calcium antagonists on the coronary microcirculation. These include their vasodilating action on coronary resistance vessels as well as their effects on extravascular resistance (i.e. intramyocardial pressure). Examples are presented of how the non-invasive measurement of myocardial blood flow and flow reserve by means of positron emission tomography (PET) can contribute to the understanding of the effects of drug treatment on the coronary microcirculation. The action of calcium antagonists on the coronary microcirculation can contribute to explain the efficacy of these drugs against ischemia and ischemia-reperfusion damage.
Authors:
O Rimoldi; P G Camici
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Herz     Volume:  24     ISSN:  0340-9937     ISO Abbreviation:  Herz     Publication Date:  1999 Nov 
Date Detail:
Created Date:  2000-02-18     Completed Date:  2000-02-18     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7801231     Medline TA:  Herz     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  522-30     Citation Subset:  IM    
Affiliation:
MRC Cyclotron Unit, Imperial College School of Medicine, Hammersmith Hospital, London, UK. ornella@cu.rpms.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Calcium Channel Blockers / administration & dosage
Coronary Circulation / drug effects,  physiology*
Humans
Microcirculation / drug effects,  physiopathology
Myocardial Ischemia / drug therapy,  physiopathology,  radionuclide imaging*
Tomography, Emission-Computed*
Vascular Resistance / drug effects,  physiology
Chemical
Reg. No./Substance:
0/Calcium Channel Blockers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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