| PET imaging of neurokinin-1 receptors with [(18)F]SPA-RQ in human subjects: assessment of reference tissue models and their test-retest reproducibility. | |
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MedLine Citation:
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PMID: 17230546 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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[(18)F]SPA-RQ (substance P antagonist receptor quantifier) labels the substance P-preferring (NK(1)) receptor in human brain. A prior study showed that [(18)F]SPA-RQ brain uptake can be quantified with a reference tissue method and thereby avoid invasive blood sampling. The purposes of this study were to compare three different reference tissue methods and to assess test-retest reproducibility. Eight healthy subjects underwent two [(18)F]SPA-RQ scans. We calculated the binding potential (BP), which is proportional to receptor density, from both regional volume of interest and voxel-wise data. We compared three reference tissue methods: simplified reference tissue model, multilinear reference tissue model (MRTM), and its two-parameter version (MRTM2). The three methods generated equivalent values of regional BP, but MRTM2 was the most resistant to noise. Temporally stable values of BP were obtained with 240 min of imaging data. MRTM2 had excellent test-retest reproducibility, with high reliability (intraclass correlation > 0.9) and low variability (< 10%). In addition to regional volume of interest analysis, we also created parametric images of BP, variability, and reliability based on voxel-wise time-activity data. The reproducibility of parametric BP was also good, with variability < 20% and reliability > 0.7 in gray matter regions. In conclusion, a two-parameter reference tissue method (MRTM2) provided reproducible and reliable measurements of [(18)F]SPA-RQ brain uptake using 240 min of both regional and voxel-wise data. |
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Authors:
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Fumihiko Yasuno; Sandra M Sanabria; Donald Burns; Richard J Hargreaves; Subroto Ghose; Masanori Ichise; Frederick T Chin; Cheryl L Morse; Victor W Pike; Robert B Innis |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Synapse (New York, N.Y.) Volume: 61 ISSN: 0887-4476 ISO Abbreviation: Synapse Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-01-24 Completed Date: 2007-04-17 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 8806914 Medline TA: Synapse Country: United States |
Other Details:
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Languages: eng Pagination: 242-51 Citation Subset: IM |
Affiliation:
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Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA. yasunof@mail.nih.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brain / radionuclide imaging* Brain Mapping* Female Fluorine Radioisotopes / pharmacokinetics* Humans Image Interpretation, Computer-Assisted / methods Linear Models Male Middle Aged Piperidines / pharmacokinetics* Positron-Emission Tomography* Receptors, Neurokinin-1 / metabolism* Reference Values Reproducibility of Results Sensitivity and Specificity Tetrazoles / pharmacokinetics* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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Z01-MH-002852-01/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/(2-fluoromethoxy-5-(5-trifluoromethyltetrazol-1-yl)benzyl)(2-phenylpiperidin-3-yl)amine; 0/Fluorine Radioisotopes; 0/Piperidines; 0/Receptors, Neurokinin-1; 0/Tetrazoles |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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