| PET imaging in a longitudinal non-Hodgkin's lymphoma study: association with tumor volume. | |
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MedLine Citation:
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PMID: 21948597 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BackgroundComputed tomography (CT) is generally used in the evaluation of the treatment response of non-Hodgkin's lymphoma (NHL) patients. Instead of morphological images, positron emission tomography (PET) shows metabolic information that is connected to tumor activity, cell proliferation rate, and, thus, prognosis.PurposeTo determine the prognostic value of PET for tumor volume reduction measured by CT and magnetic resonance imaging (MRI) along with clinical characteristics in NHL patients.Material and MethodsWe imaged 21 B-cell type NHL patients using whole-body 18F-FDG-PET at the onset and the completion of treatment and at six-month follow-up. The maximum standardized uptake value (SUV(max)) was calculated. Morphological tumor volume calculations were assessed using both MRI and CT. Additionally, patients underwent thorough clinical examination including several laboratory tests.ResultsA high SUV(max) was able to predict significant tumor volume reduction at the beginning of treatment, but the relation to pure tumor volume was poor.ConclusionThe SUV(max) values derived from FDG-PET seemed to correlate with volume changes but not with their absolute values or laboratory tests. Unlike MRI and CT, FDG-PET showed the disappearance of active tumors after treatment. |
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Authors:
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Maija Rossi; Pasi Korkola; Hannu Pertovaara; Ritva Järvenpää; Prasun Dastidar; Xingchen Wu; Seppo Soimakallio; Hannu Eskola; Pirkko-Liisa Kellokumpu-Lehtinen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-23 |
Journal Detail:
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Title: Acta radiologica (Stockholm, Sweden : 1987) Volume: - ISSN: 1600-0455 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8706123 Medline TA: Acta Radiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Medical Imaging Centre, Department of Radiology, Tampere University Hospital, Tampere. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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