Document Detail


PET and SPECT in Heart Failure.
MedLine Citation:
PMID:  23338719     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Heart failure is a serious condition with poor prognosis, which imposes an ever increasing burden on healthcare systems due to its rising prevalence. Nonetheless, physiological processes underlying heart failure remain poorly understood. In recent years, functional imaging such as gated CT has become available for routine clinical cardiology investigations. However, a maturation of nuclear imaging techniques such as PET and SPECT is now yielding new insights into the pathophysiological changes underlying heart failure, based on non-invasive measurements of myocardial blood flow, myocardial viability, sympathetic innervation, neoangiogenesis and matrix metalloproteinases activity. Investigations of these biomarkers have the potential to reveal early aspects of left ventricle remodeling; diagnosis at an earlier stage of heart failure promises to facilitate improved intervention and therapy guidance. Furthermore, nuclear imaging techniques are being developed to monitor and predict outcome of novel cell-based approaches for restorative therapy of heart failure.
Authors:
Christoph Rischpler; Stephan Nekolla; Markus Schwaiger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current cardiology reports     Volume:  15     ISSN:  1534-3170     ISO Abbreviation:  Curr Cardiol Rep     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-01-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888969     Medline TA:  Curr Cardiol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  337     Citation Subset:  IM    
Affiliation:
Department of Nuclear Medicine, Technical University, Munich, Germany, c.rischpler@tum.de.
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