| PET and SPECT in Heart Failure. | |
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MedLine Citation:
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PMID: 23338719 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Heart failure is a serious condition with poor prognosis, which imposes an ever increasing burden on healthcare systems due to its rising prevalence. Nonetheless, physiological processes underlying heart failure remain poorly understood. In recent years, functional imaging such as gated CT has become available for routine clinical cardiology investigations. However, a maturation of nuclear imaging techniques such as PET and SPECT is now yielding new insights into the pathophysiological changes underlying heart failure, based on non-invasive measurements of myocardial blood flow, myocardial viability, sympathetic innervation, neoangiogenesis and matrix metalloproteinases activity. Investigations of these biomarkers have the potential to reveal early aspects of left ventricle remodeling; diagnosis at an earlier stage of heart failure promises to facilitate improved intervention and therapy guidance. Furthermore, nuclear imaging techniques are being developed to monitor and predict outcome of novel cell-based approaches for restorative therapy of heart failure. |
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Authors:
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Christoph Rischpler; Stephan Nekolla; Markus Schwaiger |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current cardiology reports Volume: 15 ISSN: 1534-3170 ISO Abbreviation: Curr Cardiol Rep Publication Date: 2013 Mar |
Date Detail:
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Created Date: 2013-01-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888969 Medline TA: Curr Cardiol Rep Country: United States |
Other Details:
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Languages: eng Pagination: 337 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, Technical University, Munich, Germany, c.rischpler@tum.de. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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