Document Detail


PET and SPECT findings in alcohol hallucinosis: case report and super-brief review of the pathophysiology of this syndrome.
MedLine Citation:
PMID:  12607218     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Alcohol hallucinosis is a rare complication of chronic alcoholism with schizophreniform symptomatology. The pathophysiology is basically unclear. We report the case of a 48-year-old, never-medicated, long-term alcoholic suffering from alcohol hallucinosis with pure acoustic hallucinations for at least six months. Current FDG PET data suggest a hypofrontality and possibly a thalamic hypofunction in alcohol hallucinosis, findings similar to those reported in unmedicated schizophrenics. Current IBZM SPECT data do not support a dopamine receptor dysfunction in alcohol hallucinosis but TRODAT SPECT showed reduced dopamine transporter binding. Possible implications of these findings are discussed.
Authors:
M Soyka; S Dresel; M Horak; T Rüther; K Tatsch
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry     Volume:  1     ISSN:  1562-2975     ISO Abbreviation:  World J. Biol. Psychiatry     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2003-02-27     Completed Date:  2003-04-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  101120023     Medline TA:  World J Biol Psychiatry     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  215-8     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Ludwig-Maximilians-University, Nussbaumstrasse 7, 80336 Munich, Germany. michael.soyka@psy.med.uni-muenchen.de
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MeSH Terms
Descriptor/Qualifier:
Alcoholism / complications*
Benzamides / diagnostic use
Brain* / blood supply,  metabolism,  physiopathology
Fluorodeoxyglucose F18 / diagnostic use
Hallucinations / diagnosis,  etiology*,  physiopathology*
Humans
Iodine Radioisotopes / diagnostic use
Male
Middle Aged
Pyrrolidines / diagnostic use
Radiopharmaceuticals / diagnostic use
Serotonin / metabolism
Syndrome
Tomography, Emission-Computed*
Tomography, Emission-Computed, Single-Photon*
Chemical
Reg. No./Substance:
0/Benzamides; 0/Iodine Radioisotopes; 0/Pyrrolidines; 0/Radiopharmaceuticals; 50-67-9/Serotonin; 63503-12-8/Fluorodeoxyglucose F18; 84226-06-2/3-iodo-2-hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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