Document Detail


PET Quantification of Cerebral Oxygen Metabolism in Small Animals.
MedLine Citation:
PMID:  25202714     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Understanding cerebral oxygen metabolism is of great importance in both clinical diagnosis and animal experiments because oxygen is a fundamental source of brain energy and supports brain functional activities. Since small animals such as rats are widely used to study various diseases including cerebral ischemia, cerebrovascular diseases, and neurodegenerative diseases, the development of a noninvasive in vivo measurement method of cerebral oxygen metabolic parameters such as oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) as well as cerebral blood flow (CBF) and cerebral blood volume (CBV) has been a priority. Although positron emission tomography (PET) with (15)O labeled gas tracers has been recognized as a powerful way to evaluate cerebral oxygen metabolism in humans, this method could not be applied to rats due to technical problems and there were no reports of PET measurement of cerebral oxygen metabolism in rats until an (15)O-O2 injection method was developed a decade ago. Herein, we introduce an intravenous administration method using two types of injectable (15)O-O2 and an (15)O-O2 gas inhalation method through an airway placed in the trachea, which enables oxygen metabolism measurements in rats.
Authors:
Takashi Temma; Kazuhiro Koshino; Tetsuaki Moriguchi; Jun-Ichiro Enmi; Hidehiro Iida
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Publication Detail:
Type:  REVIEW     Date:  2014-8-17
Journal Detail:
Title:  TheScientificWorldJournal     Volume:  2014     ISSN:  1537-744X     ISO Abbreviation:  ScientificWorldJournal     Publication Date:  2014  
Date Detail:
Created Date:  2014-9-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101131163     Medline TA:  ScientificWorldJournal     Country:  -    
Other Details:
Languages:  ENG     Pagination:  159103     Citation Subset:  -    
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