| PET-CT vs. CT alone in ovarian cancer recurrence. | |
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MedLine Citation:
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PMID: 17404789 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: To compare fusion, positron emission tomography-computed tomography (PET-CT) with CT alone in detecting ovarian carcinoma recurrence. METHODS: Fifty-one consecutive patients underwent 53 restaging PET-CT scans with a concurrent diagnostic quality CT scan. Two body imaging radiologists independently assessed the CT's; each then teamed with a nuclear medicine specialist to review the PET-CT's. Two teams conferred for consensus on the presence of disease in the chest, abdomen, and body overall with CT alone and with PET-CT, using a six-point reader confidence metric to determine accuracy and receiver operating characteristic (ROC) curves. Reader agreement was compared using kappa. Recurrence was determined by two gynecologic oncologists reviewing clinical records from time of presentation to at least 13 months (mean 22.7) after imaging. RESULTS: Recurrence was based on histopathology in 17% (9/53). Seventy-two percent (38/53) cases had recurrence, with two cases showing isolated chest recurrence. PET-CT accuracy exceeded CT for body 92% (49/53) vs. 83% (44/53), chest 96% (51/53) vs. 89% (47/53), and abdomen 91% (48/53) vs. 79% (42/53). ROC curves for PET-CT dominated that for CT alone; this difference was statistically significant for abdomen and for body overall (P < 0.01). Interobserver agreement was better for PET-CT than for CT alone. CONCLUSIONS: PET-CT demonstrates greater accuracy and less interobserver variability than CT alone. |
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Authors:
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Sunit Sebastian; Susanna I Lee; Neil S Horowitz; James A Scott; Alan J Fischman; Joseph F Simeone; Arlan F Fuller; Peter F Hahn |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Abdominal imaging Volume: 33 ISSN: 1432-0509 ISO Abbreviation: Abdom Imaging Publication Date: 2008 Jan-Feb |
Date Detail:
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Created Date: 2007-12-21 Completed Date: 2008-01-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9303672 Medline TA: Abdom Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 112-8 Citation Subset: IM |
Affiliation:
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Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, White 270, Boston, MA 02114, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Contrast Media Female Fluorodeoxyglucose F18 / diagnostic use Humans Iopamidol / diagnostic use Middle Aged Neoplasm Recurrence, Local / radiography, radionuclide imaging Neoplasm Staging Ovarian Neoplasms / radiography*, radionuclide imaging* Positron-Emission Tomography* Predictive Value of Tests ROC Curve Radiopharmaceuticals / diagnostic use Retrospective Studies Sensitivity and Specificity Tomography, Spiral Computed* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Radiopharmaceuticals; 62883-00-5/Iopamidol; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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