| PET-CT in recurrent ovarian cancer: impact on treatment planning. | |
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MedLine Citation:
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PMID: 18751410 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Positron emission tomography-computed tomography (PET-CT) is currently not established in the management of recurrent ovarian cancer. Here, its value in diagnosis and therapy planning was evaluated. PATIENTS AND METHODS: Seventy patients received PET-CT for suspicion of recurrent ovarian cancer. PET-CT and surgery were reviewed to analyze the accuracy in the diagnosis of recurrence and prediction of full resectability. RESULTS: PET-CT showed disease relapse in 63 of 70 patients, with full sensitivity and specificity. Thirty cases were operated on. PET-CT indicated full resectability in 24, but in fact only incomplete resection was possible in three cases. Thus sensitivity and specificity for the identification of full resectability were 100% and 66%, respectively. Seven negative results in PET-CT were confirmed by a relapse-free follow-up of 1 year. CONCLUSION: PET-CT offers reliable detection of recurrent ovarian cancer. Although diagnostic accuracy in the prediction of full resectability is limited, surgical planning is improved by identifying sites of intraperitoneal involvement. |
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Authors:
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Miriam S Lenhard; Alexander Burges; Thorsten R C Johnson; Petra Stieber; Carolin Kümper; Nina Ditsch; Rainer Linke; Klaus Friese |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anticancer research Volume: 28 ISSN: 0250-7005 ISO Abbreviation: Anticancer Res. Publication Date: 2008 Jul-Aug |
Date Detail:
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Created Date: 2008-08-28 Completed Date: 2008-09-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
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Languages: eng Pagination: 2303-8 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Ludwig Maximilians University Munich, Campus Grosshadem, Munich, Germany. Miriam.Lenhard@med.uni-muenchen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Combined Modality Therapy Female Fluorodeoxyglucose F18 / diagnostic use Humans Middle Aged Neoplasm Recurrence, Local / drug therapy, radionuclide imaging*, surgery, therapy* Ovarian Neoplasms / drug therapy, radionuclide imaging*, surgery, therapy* Positron-Emission Tomography / methods Radiopharmaceuticals / diagnostic use Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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