| PET-CT-guided interventions in the management of FDG-positive lesions in patients suffering from solid malignancies: initial experiences. | |
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MedLine Citation:
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PMID: 19238391 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Positron emission tomography-computed tomography (PET-CT) has gained widespread acceptance as a staging investigation in the diagnostic workup of malignant tumours and may be used to visualize metabolic changes before the evolution of morphological changes. To make histology of PET findings without distinctive structural changes available for treatment decisions, we developed a protocol for multimodal image-guided interventions using an integrated PET-CT machine. We report our first experience in 12 patients admitted for staging and restaging of breast cancer, non-small cell lung cancer, cervical cancer, soft tissue sarcoma, and osteosarcoma. Patients were repositioned according to the findings in PET-CT and intervention was planned based on a subsequent single-bed PET-CT acquisition of the region concerned. The needle was introduced under CT guidance in a step-by-step technique and correct needle position in the centre of the FDG avid lesion was assured by repetition of a single-bed PET-CT acquisition before sampling. The metabolically active part of lesions was accurately targeted in all patients and representative samples were obtained in 92%. No major adverse effects occurred. We conclude that PET-CT guidance for interventions is feasible and may be promising to optimize the diagnostic yield of CT-guided interventions and to make metabolically active lesions without morphological correlate accessible to percutaneous interventions. |
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Authors:
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Bernd Klaeser; Michel D Mueller; Ralph A Schmid; Carlos Guevara; Thomas Krause; Jakub Wiskirchen |
Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-02-24 |
Journal Detail:
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Title: European radiology Volume: 19 ISSN: 1432-1084 ISO Abbreviation: Eur Radiol Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-05 Completed Date: 2009-08-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9114774 Medline TA: Eur Radiol Country: Germany |
Other Details:
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Languages: eng Pagination: 1780-5 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Female Fluorodeoxyglucose F18 / diagnostic use* Humans Male Middle Aged Neoplasms / diagnosis*, surgery* Pilot Projects Positron-Emission Tomography / methods* Radiopharmaceuticals / diagnostic use Sensitivity and Specificity Subtraction Technique Surgery, Computer-Assisted / methods* Tomography, X-Ray Computed / methods* Treatment Outcome Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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