| PET-CT as an effective imaging modality in the staging and follow-up of post-transplant lymphoproliferative disorder following solid organ transplantation. | |
| | |
MedLine Citation:
|
PMID: 20087557 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
INTRODUCTION: To establish the role of positron-emission tomography (PET)-computed tomography (CT) in post-transplant lymphoproliferative disorder (PTLD) patients, compared to conventional imaging (ultrasonography/CT/magnetic resonance imaging) in relation to its accuracy, sensitivity and specificity. METHODS: 30 patients (26 males and 4 females), with a median age of 49.5 (range 18-74) years, were retrospectively evaluated. In 29 cases, the diagnosis was confirmed by histopathology. Malignant lymphoma was detected in 20 cases, polymorphic lymphoproliferative disorder in six cases, multiple myeloma in two cases and Hodgkin's disease in one case. A total of 49 PET-CTs (13 studies for staging at diagnosis and 36 studies at follow-up as assessment post-therapy) were compared to conventional imaging. Imaging results in accordance with disease status were assessed at a median follow-up of 17.8 (range 1.5-42.2) months post-PET-CT. RESULTS: In 41 of 49 examinations performed for staging and on follow-up, PET-CT and conventional imaging findings were concordant. Compared to conventional imaging, PET-CT showed comparable sensitivity (75 percent vs. 83 percent), similar specificity (100 percent in both modalities) and comparable accuracy (77 percent vs. 85 percent) during staging at diagnosis. PET-CT was found to be superior to conventional imaging modalities at follow-up, with greater sensitivity (100 percent vs. 81 percent), specificity (80 percent vs. 100 percent) and accuracy (97 percent vs. 83 percent). CONCLUSION: PET-CT is an accurate diagnostic tool for staging and for the follow-up of PTLD patients. It represents a good alternative imaging method to avoid contrast-related nephrotoxicity in patients who often develop impaired renal function secondary to chronic immunosuppressive therapy. However, further studies are recommended before considering PET-CT as a routine diagnostic tool in PTLD. |
| | |
Authors:
|
A R Noraini; E Gay; C Ferrara; E Ravelli; V Mancini; E Morra; P Muti; A Tahir; N Abdul Jalil; C Rossetti |
Related Documents
:
|
15750157 - The diabetic foot: initial experience with 18f-fdg pet/ct. 16635407 - The role of 11c-choline positron emission tomography-computed tomography and videomedia... 17060487 - A prospective study of pet/ct in initial staging of small-cell lung cancer: comparison ... 8683307 - Nodal spread of squamous cell carcinoma of the oral cavity detected with pet-tyrosine, ... 10928607 - Lymphocytic interstitial pneumonia: follow-up ct findings in 14 patients. 15552117 - Quantitative brain fdg/pet studies using dynamic aortic imaging. |
Publication Detail:
|
Type: Evaluation Studies; Journal Article |
Journal Detail:
|
Title: Singapore medical journal Volume: 50 ISSN: 0037-5675 ISO Abbreviation: Singapore Med J Publication Date: 2009 Dec |
Date Detail:
|
Created Date: 2010-01-20 Completed Date: 2010-05-19 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0404516 Medline TA: Singapore Med J Country: Singapore |
Other Details:
|
Languages: eng Pagination: 1189-95 Citation Subset: IM |
Affiliation:
|
Department of Diagnostic Imaging, Serdang Hospital, Jalan Puchong, Serdang 43000, Malaysia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged False Negative Reactions False Positive Reactions Female Humans Immunocompromised Host* Lymphoma / immunology*, radiography*, ultrasonography Magnetic Resonance Angiography Male Middle Aged Organ Transplantation* Positron-Emission Tomography / methods* Predictive Value of Tests Tomography, X-Ray Computed* Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Self-expanding nitinol stents in recanalisation of long-length superficial femoral artery occlusions...
Next Document: Proteomic evidence of bacterial peptide translocation in afebrile patients with cirrhosis and ascite...