| PERK in beta cell biology and insulin biogenesis. | |
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MedLine Citation:
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PMID: 20850340 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PERK (EIF2AK3) was originally discovered as a major component of the unfolded protein response (UPR). PERK deficiency results in permanent neonatal diabetes, which was initially thought to be caused by a failure to regulate ER stress in insulin-secreting beta cells, culminating in beta cell death. However, subsequent studies found that low beta cell mass was a result of reduced cell proliferation, rather than increased apoptosis. Genetic and cellular studies of Perk-deficient beta cells showed that PERK was crucially required for ER functions including proinsulin trafficking and quality control, unrelated to the ER stress pathway. Under normal physiological conditions, changes in ER calcium levels, mediated by glucose and other insulin secretagogues, regulate PERK activity for the purpose of controlling insulin biogenesis. |
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Authors:
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Douglas R Cavener; Sounak Gupta; Barbara C McGrath |
Publication Detail:
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Type: Journal Article; Review Date: 2010-09-17 |
Journal Detail:
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Title: Trends in endocrinology and metabolism: TEM Volume: 21 ISSN: 1879-3061 ISO Abbreviation: Trends Endocrinol. Metab. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-24 Completed Date: 2011-03-15 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 9001516 Medline TA: Trends Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 714-21 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Biology, Center for Cellular Dynamics, Pennsylvania State University, University Park, PA 16802, USA. drc9@psu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Humans Insulin / biosynthesis* Insulin-Secreting Cells / enzymology* Models, Biological eIF-2 Kinase / genetics, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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R01 DK062049-03/DK/NIDDK NIH HHS; R01 DK088140-02/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Insulin; EC 2.7.10.-/PERK kinase; EC 2.7.11.1/eIF-2 Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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